Flashcards in Adrenal Pharmacology Deck (13):
The most common cause of secondary adrenal insufficiency is _____________.
pharmacologic doses of glucocorticoids
Among steroids, the ___________ effects can be separated from ___________ effects.
Which two steroids (of the ones listed in Dr. French's chart) have no salt-retaining effects?
Triamcinolone and dexamethasone
Where is the cellular receptor for glucocorticoids?
In the cytosol, but it moves into the nucleus upon binding
Cortisol stimulates contrary processes in the liver. Explain.
It stimulates gluconeogenesis and glycogen synthesis.
The kidney has the enzyme _____________ to allow it not be affected by the mineralocorticoid function of cortisol.
11-beta hydroxysteroid dehydrogenase
Which adrenal hormones will be absent in 21-hydroxylase deficiency?
Aldosterone and cortisol
Without 17-alpha hydroxylase you don't get _____________.
cortisol or androgens
Describe the three pharmacologic things you can do for those with pheochromocytoma.
Beta-blockade (once alpha blockade is sufficient)
Calcium channel blockers (for inadequate BP control)
There are two kinds of 11-beta hydroxysteroid dehydrogenase. Which is deactivating?
Lack of 17-alpha dehydrogenase results in what clinical picture?
Lack of 21 hydroxylase results in what clinical picture?