Adrenal Pharmacology Flashcards Preview

Digestive, Endocrine, and Metabolic Systems > Adrenal Pharmacology > Flashcards

Flashcards in Adrenal Pharmacology Deck (13):
1

The most common cause of secondary adrenal insufficiency is _____________.

pharmacologic doses of glucocorticoids

2

Among steroids, the ___________ effects can be separated from ___________ effects.

anti-inflammatory; mineralocorticoids

3

Which two steroids (of the ones listed in Dr. French's chart) have no salt-retaining effects?

Triamcinolone and dexamethasone

4

Where is the cellular receptor for glucocorticoids?

In the cytosol, but it moves into the nucleus upon binding

5

Cortisol stimulates contrary processes in the liver. Explain.

It stimulates gluconeogenesis and glycogen synthesis.

6

The kidney has the enzyme _____________ to allow it not be affected by the mineralocorticoid function of cortisol.

11-beta hydroxysteroid dehydrogenase

7

Which adrenal hormones will be absent in 21-hydroxylase deficiency?

Aldosterone and cortisol

8

Without 17-alpha hydroxylase you don't get _____________.

cortisol or androgens

9

Describe the three pharmacologic things you can do for those with pheochromocytoma.

Alpha-blockade
Beta-blockade (once alpha blockade is sufficient)
Calcium channel blockers (for inadequate BP control)

10

There are two kinds of 11-beta hydroxysteroid dehydrogenase. Which is deactivating?

11-B HSD2

11

Lack of 17-alpha dehydrogenase results in what clinical picture?

Non-virilizing hypertension

12

Lack of 21 hydroxylase results in what clinical picture?

Virilizing hypotension

13

Lack of 11-beta hydroxylase results in what clinical picture?

Virilizing hypertension

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