Treatment of Dyslipidemias Flashcards Preview

Digestive, Endocrine, and Metabolic Systems > Treatment of Dyslipidemias > Flashcards

Flashcards in Treatment of Dyslipidemias Deck (17):
1

When triglycerides are high, ______ tends to be low.

HDL

2

Describe briefly the recommendations for statin therapy.

High intensity:
- LDL greater than 190 or
- Clinical ASCVD

Moderate/high:
- Diabetic between 40 and 75 years of age

Moderate:
- Non-diabetic; age 40 - 75 with LDL 70-189 and + 7.5% extra risk of CVD

3

This is important! With each doubling of statin dose, the LDL is reduced by ______.

6%

4

What is the difference between myositis and rhabdomyolysis?

Both present with muscle pain, weakness, and elevated creatine kinase, but the creatine kinase is 50-fold increased.

5

Statins can precipitate an earlier onset of _______.

T2DM, but the benefit outweighs the risk

6

How do bile acid sequestrants work?

They have lots of quaternary amines that give up chloride and bind dietary cholesterol.

7

How does ezetimibe work?

It gets absorbed from the gut by the same receptor as cholesterol, so it competes with cholesterol and decreases cholesterol's absorption.

8

True or false: ezetimibe has no clinical benefit.

False. It has been shown to decrease CVD events by 2.0%; this is a modest effect, but it is used.

9

Alirocumab has been shown to decrease LDL by ________.

60% (this is a PCSK9 inhibitor)

10

Microsomal transfer protein (MTP) allows the ____________.

triglycerides to be incorporated into the particle

11

MTP inhibitors cause ___________.

the VLDL to remain stuck in hepatocytes, because it's not mature

12

How do statins affect triglycerides?

Low doses don't change triglycerides, but high-dose one lower it.

13

Fibrates work by _________________.

activating PPAR alpha which stimulates fatty acid oxidation

14

The people who benefit from fibrates are those with ______________.

high triglycerides (greater than 200) and low HDL

15

How does eating fish oil help with blood lipids?

It decreases hepatic production of triglycerides and therefore VLDL secretion.

16

The classic side effect of niacin therapy is _____________.

facial redness

17

Four lifestyle modifications that have been shown to be effective in raising HDL are _____________.

exercise (10%), sustained weight loss (2%), alcohol intake (5% - 10%), and smoking cessation (10%)

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