Pituitary Pathology Flashcards Preview

Digestive, Endocrine, and Metabolic Systems > Pituitary Pathology > Flashcards

Flashcards in Pituitary Pathology Deck (19):
1

Why is the posterior pituitary called the pars nervosa?

Because it originates from the nervous tissue!

2

The anterior pituitary has what histologic pattern? Why is this clinically helpful?

It has a honeycomb-like reticulin network that allows pathologists to distinguish it from tumors of the anterior pituitary (which will lose this structure).

3

The ____________ pituitary does not have as rich a network of blood vessels.

posterior (because it's mostly axons)

4

Pituitary adenomas are WHO grade ____.

I (easily resectable), although they are not given this designation usually because that system is reserved for CNS tumors

5

Invasive macroadenomas can invade ____________.

bone

6

95% of pituitary adenomas are ____________.

sporadic

7

What is touch preparation?

If a sample of the pituitary has an adenoma, then simply touching a cytologic glass slide to it will cause shedding of cells.

8

Advanced pathology labs can determine which lineage of tumor the pituitary adenoma arose from by ___________.

staining for transcription factors: T-pit = corticotroph, Pit-1 = somatotroph, and SF-1 = gonadotroph

9

Prolactinemia can arise from three things: ________________.

pituitary tumors, dopamine antagonists, and infundibular compression (because it disrupts the tonic inhibition)

10

To develop true gigantism, you need to develop a pituitary adenoma before _______________.

the epiphyseal plate stops growing

11

Why might a prolactinoma not respond to bromocriptine or cabergoline?

If it is a mixed adenoma (with growth hormone somatotrophic cells)

12

Those with corticotroph adenomas might have what cell on histologic examination of their anterior pituitary?

Crooke cells – cells that change their morphology in response to high levels of cortisol

13

The cystic tumor that arises from the Rathke pouch is called ___________.

craniopharyngioma

14

Metastasis to endocrine glands is not common, but the most common cancer to do so is _____________.

breast cancer

15

85% of sellar masses are _______________.

pituitary adenomas

16

All sellar region masses preferentially affect adults with the exception of ________________.

craniopharyngioma

17

All multiple endocrine neoplasias have ___________ inheritance.

autosomal dominant

("All MEN are Dominant")

18

What do Pit-1 and SF-1 stain for?

Pit-1: somatotroph
SF-1: gonadotroph

19

The most common non-functional pituitary adenoma is ______________.

gonadotroph adenoma (most are positive for SF-1 and negative for all hormones)

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