Flashcards in Pituitary Pathology Deck (19):
Why is the posterior pituitary called the pars nervosa?
Because it originates from the nervous tissue!
The anterior pituitary has what histologic pattern? Why is this clinically helpful?
It has a honeycomb-like reticulin network that allows pathologists to distinguish it from tumors of the anterior pituitary (which will lose this structure).
The ____________ pituitary does not have as rich a network of blood vessels.
posterior (because it's mostly axons)
Pituitary adenomas are WHO grade ____.
I (easily resectable), although they are not given this designation usually because that system is reserved for CNS tumors
Invasive macroadenomas can invade ____________.
95% of pituitary adenomas are ____________.
What is touch preparation?
If a sample of the pituitary has an adenoma, then simply touching a cytologic glass slide to it will cause shedding of cells.
Advanced pathology labs can determine which lineage of tumor the pituitary adenoma arose from by ___________.
staining for transcription factors: T-pit = corticotroph, Pit-1 = somatotroph, and SF-1 = gonadotroph
Prolactinemia can arise from three things: ________________.
pituitary tumors, dopamine antagonists, and infundibular compression (because it disrupts the tonic inhibition)
To develop true gigantism, you need to develop a pituitary adenoma before _______________.
the epiphyseal plate stops growing
Why might a prolactinoma not respond to bromocriptine or cabergoline?
If it is a mixed adenoma (with growth hormone somatotrophic cells)
Those with corticotroph adenomas might have what cell on histologic examination of their anterior pituitary?
Crooke cells – cells that change their morphology in response to high levels of cortisol
The cystic tumor that arises from the Rathke pouch is called ___________.
Metastasis to endocrine glands is not common, but the most common cancer to do so is _____________.
85% of sellar masses are _______________.
All sellar region masses preferentially affect adults with the exception of ________________.
All multiple endocrine neoplasias have ___________ inheritance.
("All MEN are Dominant")
What do Pit-1 and SF-1 stain for?