Flashcards in Obesity Treatment: Drugs, Surgical Options, and Popular Diets Deck (24):
Not related to this lecture: at 6"2, what should your weight maximally be to avoid weight-related complications?
178 lbs (a BMI of 22.9); a BMI of 23 is where weight-related complications are known to start increasing
When counseling a patient on medications to assist in weight loss, you should be sure the patient understands that the drugs must be taken _____________.
chronically; typically, when patients stop taking these medications, their weight returns
One common reason people don't take weight-loss medications is _______________.
that insurance companies won't pay for them and they're extremely expensive
Which weight-loss drug is chemically related to amphetamine?
Side effects of phentermine include headache, hypertension, and nervousness. This makes sense, because phentermine is _____________.
How does orlistat work?
It inhibits pancreatic lipase, thereby decreasing fat absorption.
Side effects of orlistat include ______________.
increasing urgency of stooling and steatorrhea
Which weight-loss drug is the safest?
Orlistat (it's actually available OTC)
Why was phen/fen removed from the market?
It (mostly the fen) caused valvular heart disease.
____________ works by binding to and activating serotonin 2C receptors.
The most effective weight-loss medication is ___________.
topiramate/phentermine (can go up to 12%); this combination also raises HDL, lowers BP, and decreases glucose levels
Weight-loss drugs also reduce _____________.
A1c (Dr. Bessesen showed the trial for naltrexone/bupropion)
The most popular kind of stomach surgery is ____________.
The most effective stomach surgery is _____________.
Why is gastric surgery effective?
Because they aren't secreting ghrelin!
Long-term studies on gastric-bypass surgery show that ______________.
compared to controls, those who had gastric bypass have fewer cases of diabetes, MI, and cancer
What is the mortality of gastric bypass surgery?
One of the downsides of phentermine is that ____________.
there is no data on long-term safety
Women need to have a negative pregnancy test before taking ________.
Which weight-loss drug is the cheapest? Most effective? Safest? Has the fewest side effects?
Has the fewest side effects: lorcaserin
Most effective: phentermine/topiramate
Avoid phentermine in patients with _________ problems.
Paresthesias are a side effect of which weight-loss medication?
Which drug is considerate to have intermediate effectiveness and safety and is thus a second-line option?