Small Group: Lipids and Obesity Cases Flashcards Preview

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Flashcards in Small Group: Lipids and Obesity Cases Deck (10):
1

What are the four categories of people who have been shown to benefit from statins?

- History of ASCVD
- Age 40-75 with diabetes; LDL greater than 70
- Age 40-75 with 10-year risk of CVD greater than 7.5%; LDL greater than 70
- LDL greater than 190

2

What is combined dyslipidemia?

It can be familial dysbetalipoproteinemia (if the triglycerides and total cholesterol are extremely high), or it can be a non-specific, polygenic disorder.

3

How do fibrates work?

Fibrates, such as gemfibrozil, stimulate lipoprotein lipase ("FIBbing makes you a LIar"). Thus, they break down VLDL and raise HDL.

4

What medication can raise triglyceride levels?

Estrogen

5

What are five things that can increase triglyceride levels?

- Estrogen
- Alcohol
- T2DM (poorly controlled)
- Renal failure
- Hypothyroidism

6

What is apoC2?

It is a ligand on apolipoprotein B100 that binds to lipoprotein lipase. Without it, patients will have hypertriglyceridemia.

7

Of hypertension, obesity, and dyslipidemia, which has the strongest correlation with insulin resistance?

Hypertension

8

A 500 kcal deficit per day is equal to one pound ________.

per week

9

Describe familial dysbetalipoproteinemia.

A mutation in apoE2 leads to failure of VLDL, IDL, LDL, and chylomicrons to be reabsorbed by the liver and subsequently triglyceride and cholesterol levels will rise.

10

Triglyceride levels over _______ should be treated to prevent pancreatitis.

500

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