Flashcards in Small Group: Lipids and Obesity Cases Deck (10):
What are the four categories of people who have been shown to benefit from statins?
- History of ASCVD
- Age 40-75 with diabetes; LDL greater than 70
- Age 40-75 with 10-year risk of CVD greater than 7.5%; LDL greater than 70
- LDL greater than 190
What is combined dyslipidemia?
It can be familial dysbetalipoproteinemia (if the triglycerides and total cholesterol are extremely high), or it can be a non-specific, polygenic disorder.
How do fibrates work?
Fibrates, such as gemfibrozil, stimulate lipoprotein lipase ("FIBbing makes you a LIar"). Thus, they break down VLDL and raise HDL.
What medication can raise triglyceride levels?
What are five things that can increase triglyceride levels?
- T2DM (poorly controlled)
- Renal failure
What is apoC2?
It is a ligand on apolipoprotein B100 that binds to lipoprotein lipase. Without it, patients will have hypertriglyceridemia.
Of hypertension, obesity, and dyslipidemia, which has the strongest correlation with insulin resistance?
A 500 kcal deficit per day is equal to one pound ________.
Describe familial dysbetalipoproteinemia.
A mutation in apoE2 leads to failure of VLDL, IDL, LDL, and chylomicrons to be reabsorbed by the liver and subsequently triglyceride and cholesterol levels will rise.