Flashcards in Small Groups: Adrenal Disorders Deck (10):
One of the features that makes it difficult to confirm diagnosis of pheochromocytoma is ______________.
that the tumor only secretes catecholamines episodically, so there might not be excess catecholamines the moment you check for them
High levels of what molecule suggest malignant pheochromocytoma?
A very high DHEA level suggests _______________.
an adrenal tumor that primarily secretes androgens
Why should you initially give dexamethasone to someone with suspected adrenal insufficiency?
Because dexamethasone does not show up as cortisol in cortrosyn stimulation tests, you would still be able to differentiate the cause of the patient's adrenal insufficiency.
__________ withdrawal can mimic the symptoms of pheochromocytoma.
Conn's syndrome accounts for about ________ percent of cases of hypertension.
5% - 10%
Explain the pathophysiology of glucocorticoid-remediable hyperaldosteronism.
An autosomal dominant disorder in which aldosterone synthase gets fused with the ACTH-induced 11-beta-hydroxylase. Giving glucocorticoids decreases the release of ACTH and thus down-regulates the aberrant enzyme.
Addison's disease is characterized by these symptoms: ___________________.
weakness, fatigue, nausea, anorexia, dizziness, and abdominal pain
What symptoms suggest adrenal crisis?
Hypotension, fever, and confusion (administer 100 mg hydrocortisone)