Thyroid Pharmacology Flashcards Preview

Digestive, Endocrine, and Metabolic Systems > Thyroid Pharmacology > Flashcards

Flashcards in Thyroid Pharmacology Deck (24):
1

Thyroid hormones are best absorbed by the _____________.

ileum

2

Levothyroxine should be taken on a(n) ______________.

empty stomach

3

What impairs the absorption of levothyroxine?

Metal cations
Ciprofloxacin

4

The activating deiodinases are inhibited by _______________.

glucocorticoids, beta-blockers, amiodarone, caloric deprivation, and chronic illness

5

T4 requires ___________ to become effective.

6-8 weeks

6

Be careful giving T4 to those with ____________.

underlying cardiac illness

7

Why is it necessary to give increased doses of T4 to pregnant women?

Because the excess estrogen induces greater thyroid-binding globulin and excess metabolism of thyroxine

8

If you give a large dose of thyroxine to someone having a thyroid crisis, what else do you need to give?

Corticosteroids to prevent adrenal insufficiency

9

There is no evidence to support that the brand name of thyroxine ____________.

is superior

10

The pharmaceutic name for triiodothyronine is ____________.

liothyroxine

11

Which has better bioavailability, T3 or T4?

T3

12

Why is T3 more potent than T4?

It has a higher affinity for thyroid-hormone receptors.

13

How do methimazole and propylthiouracil work?

They inhibit thyroid peroxidase, specifically where it organifies iodide.

14

What can lead to permanent destruction of the thyroid?

I(131) – radioactive iodide

15

Which thyroid peroxidase inhibitor is best for pregnant women?

Propylthiouracil (Pregnancy = Propylthiouracil)

16

Doctors occasionally give __________ before administering radioactive iodine.

TSH

17

What causes unbinding from TBG?

Phenytoin
Carbamazepine
Furosemide
Glucocorticoids

18

What drugs can cause euthyroid sick syndrome?

Beta-blockers
Amiodarone
PTU
Glucocorticoids

19

The other name for T3 is _____________.

liothyronine

20

Methimazole is generally the preferred medication because of lack of ______________.

hepatotoxicity, efficacy at lower doses, and once-daily dosing

21

_________, which rises in pregnancy, stimulates production of TBG.

Estrogen

22

Remember that methimazoles and thionamides are only for hyperthyroidisms from excess _____________.

production, not release

23

The most dangerous side effect of methimazole and PTU is _____________.

agranulocytosis

24

What is SSKI?

Super-saturated potassium iodide

This is only used in thyroid storms.

Decks in Digestive, Endocrine, and Metabolic Systems Class (133):