GI Tract and Systemic Immunity Flashcards Preview

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Flashcards in GI Tract and Systemic Immunity Deck (23):
1

An uncommitted T cell is given the nomenclature _____.

Th0

2

One activated T-helper cell becomes _________ cells in four days.

64,000

3

Which five main cells can Th0 cells become?

Th1
Th2
Treg
Th17
Thf

4

At the site of antigen, activated Th1 cells release ___________.

interferon-gamma (which attracts M1 macrophages) and IL-2 (which activates cytotoxic T cells)

5

Which macrophage subtype is aggressive?

M1

6

The main helper T cell involved in psoriasis is _____.

Th17

7

It's thought that ulcerative colitis results from ______________.

an immune system response to commensal bacteria

8

Activated Th2, at the site of antigen, releases ___________.

IL-4 (attracting eosinophils and macrophages) and IL-13 (stimulating IgE production)

9

Three immune cell types are involved in asthma: _________________.

Th2, M2 macrophages, and eosinophils

10

True or false: Th17 is another regulatory T cell that helps reduce the lymph node response.

False. Th17 is a very strong inflammatory T cell.

11

A Th0 cell in the thymus that binds to peptide/MHC with high affinity ________. A Th0 cell in the gut that binds peptide/MHC in the presence of TGFbeta only turns into a _________. A Th0 cell in the gut that binds peptide/MHC in the presence of TGFbeta and IL-6 turns into a __________.

dies; iTreg; Th1, Th2, or Th17

12

Differentiate Treg and iTreg.

Treg: a Treg cell that arises in the thymus

iTreg: a Treg that is induced in the periphery

13

Normal gut tissue creates _________ that makes an environment favorable for Tregs.

TGFbeta

14

The recurring theme in research on the causes of IBD is ___________.

leaking gut – allowing bacteria through

15

What does TTG do?

Tissue transglutaminase catalyzes the reaction that converts glutamine to glutamic acid – a deamidation reaction – in the gliadin peptide (position 6).

16

Describe the role of follicular helper T cells (Tfh).

They normally reside in the paracortex of the lymph node, and when they bind antigen they migrate to the follicles and active B cells to make immunoglobulin.

17

Tregs make two important anti-inflammatory cytokines: _______.

IL-10 and TGFbeta

18

CTLs kill cells but also secrete what signaling molecule?

Interferon-gamma (to attract macrophages to come eat the cells they've killed)

19

Most of the complementarity of the T cell receptor is in CDR______.

3

20

What determines the pathway of the Th0 cell?

The particular history of the dendritic cell that presented antigen

21

There is normally abundant ______ in the gut and ________ secreted by gut dendritic cells that promotes Treg develop in Peyer's patches.

TGFbeta; IL-10

22

TGFbeta and ______ in the gut leads to development of Th0 cells into Th1 and Th17.

IL-6 (released by damaged epithelium)

23

If your body makes IgE to _____________ after a tick bite, then you'll become allergic to meat.

galactose-alpha-1,3-galactose

Decks in Digestive, Endocrine, and Metabolic Systems Class (133):