Flashcards in Thyroid Dysfunction Deck (14):
Which deiodinase deactivates T4?
Type 3 deiodinase (which creates reverse T3)
What can promote a shift to type 3 deiodinase?
What percent of T4 is free?
Decreased thyroid binding proteins can cause ___________.
The normal range of TSH is _____________.
0.4 - 4.0 (treat if greater than 10)
What is the best test for thyroid dysfunction?
TSH (provided the pituitary does not show other signs of dysfunction)
_______________ leads to an increased expression of NIS.
TSH (NIS is Na-Iodide Symporter)
Thyrotoxicosis presents with _________________.
low TSH and high T3/T4
If TSH is low but the thyroid is still taking up iodide, then this is ________________.
true hyperthyroidism, characterized by the autonomous production of thyroid hormone
Deposition of hyaluronic acid in the anterior calves leads is called ____________ and is pathognomonic for Graves' disease.
The activating deiodinases are _________.
types I and II
What lab pattern is suggestive of subclinical hyperthyroidism?
(Similarly, subclinical hypothyroidism presents with elevated TSH but normal T4 and T3.)
Which cell type mediates the damage in Hashimoto's?