Endocrine Pathology Flashcards Preview

Digestive, Endocrine, and Metabolic Systems > Endocrine Pathology > Flashcards

Flashcards in Endocrine Pathology Deck (25):
1

In general, how are endocrine/neuroendocrine cells described?

- Nested
- Salt-and-pepper nuclei
- Monomorphic

2

The thyroid follicular cells are _________________.

cuboidal, low columnar

3

On histologic exam, the thyroid of someone with Grave's disease will appear ______________.

more cellular and with colloid scalloping

4

Why do germinal centers form in the thyroids of those with Hashimoto's?

Because it is a lymphocytic infiltrate that causes the thyroiditis!

5

How will oncocytic metaplasia appear?

As a pinkening of the cytoplasm

6

DeQuervain's will present with what unique cell type?

Giant, multinucleated cells (granulomas)

7

The colloids can expand in those with _______________.

hypothyroidism

8

True or false: follicular adenoma can transition to follicular carcinoma.

False.

9

Follicular carcinoma is distinguished by ______________.

invasion through the capsule

10

Papillary thyroid carcinoma is characterized by __________ features, not the papillary architecture, strangely.

nuclear

11

The papillae have ___________ cores.

fibrovascular

12

Which thyroid carcinoma has the worst prognosis?

Anaplastic – only three months

13

Recall that ______________ appears as monomorphic cells in nests of amyloid.

medullary thyroid carcinoma

14

The parathyroids are 25% ______________.

adipose tissue

15

Parathyroid adenomas will present with decreased _____________ and increased _____________.

adiposity; cellularity

16

Brown tumors will have the same histologic presentation as ____________.

giant cell tumors

17

How does small cell carcinoma of the lung appear?

Densely packed, blue nuclei with high N:C ratio

18

How do adrenal adenomas and carcinomas differ?

Carcinomas are more often bigger, necrotic, and invasive

19

Treating adrenal adenoma with spironolactone can lead to what on pathologic exam?

Spironolactone bodies – areas of endoplasmic reticulum swirled into little bodies

20

What causes Waterhouse-Friederichsen syndrome?

Bilateral adrenal hemorrhage from N. meningitidis

21

Which MEN syndrome has Marfanoid body?

MEN2B (Body haBitus = 2B)

22

Thyroid medullary cells are also called ___________.

C-cells

23

Recall that in DiGeorge both the thymus and the __________ fail to develop. Why?

parathyroid; because both develop from the same pharyngeal pouches (3 and 4)

24

What are the (supposedly outdated) rules of 10%?

In pheochromocytoma
- 10% are bilateral
- 10% are extra-adrenal
- 10% are not associated with hypertension
- 10% are malignant

25

The only definitive sign that pheochromocytoma is malignant is _______________.

metastasis

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