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Flashcards in Blood Deck (21):
1

What is a rouleuax formation

Long line of RBCs stacked

At least 1 association is multiple myeloma

2

Beta Thal Major labs

NO Hb A

↑ Hb A2 (a2d2) and Hb F (a2g2)

b/c there are no beta chains to make HbA

3

What are the features of hairy cell leukemia

massive spleen
"dry tap" of bone marrow
lymph with cytoplasmic projections

4

Does AML cause hepatosplenomegaly

not usually

5

vWF deficiency labs

↑ Bleeding time (plt adhesion problem )

↑ PTT (Factor 8 needs vWF)

Autosomal Dom Inheritance
Most common inherited bleeding disorder

6

This is an x linked deficiency in factor VIII

Hemophilia A

↑ PTT
Normal Bleeding time

7

This is an X linked deficiency in IX

Hemophilia B

↑ PTT
Normal Bleeding Time

cannot convert prothrombin to thrombin
Giving thrombin will help

8

What is Raltegravir

HIV drug
Integrase inhibitor
Disrupts hiv from integrating into host cell chromosome

9

What stain is used in AML

Myeloperoxidase

Auerrods seen in abundance

10

What is terminal deoxynucleotide transferase

it adds nucleotides in V D J antibody genes

Markes immaute B and T cells
Ex: ALL

11

How do you help a hemophiliac clot

ultimitly, the problem is that they are not making thromin from prothrombin

SO, give thrombin --> clot =)

12

What must you always rule out in cases of Iron deficiency

THE CAUSE

Look for bleeding first (since its emergenct)\

Plummer vinson can do this too
Chronic disease, etc

13

What does an RB protein do

When it is hyperphosphorylated, it is OFF

When it is OFF, G1--> S phase

14

What does C-Myc do

transcription activator

On too much in burkit

15

What does BCL2 do

It STOPS apoptosis

Too much BCL2 in folicular lymphoma

16

What is wrong in Mantle Cell lymphoma

↑ Cyclin D
G1--> S

17

What does Interferon A do

made by leauks
Anti-viral and anti-tumor

18

What does transforming growth factor beta do

inhibits inflammatory response
Decreases T cells

19

What mediates cachexia

TNF a
Suppresses appetite

20

What does ristocetin do

Activates vWF to bind GpIb

If ritocetin is added and nothing happens/ no aglutination--> van Willebrand or Bernard Soulier syndrome

21

What helps differentiate osteoclasts

Mac Stimulating factor and NF kappa B ligand (RANK) play an important role in differentiating osteoclasts