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Flashcards in Morgan Wins at Biochem Deck (23):
1

What causes hemoglobin c

single aa substitution in Hb

2

What is the mutation seen in HbS

Valine replaces glutamic acid

promotes hydrophobic rxn between hemoglobins--> sickling

3

What controls the balance between gluconeogenesis and glycolysis

Fructose 2,6- bisphosphate, which regulates phosphofructokinase 1

4

name a thing b12 does biochem like with blood

methylmalonyl coa-- (b12 and MM CoA mutase) --> succinyl coa

this rxn goes to make heme

5

Most common urea cycle disorder

ornithine transcarbamylase deficiency

X linked

body can't eliminate ammonia well

6

If you dont eat it, how else can you get niacin

Tryptophan makes niacin (needs b2 and b6)

7

What does mTOR do

iL-2 --> mTOR--> gene

8

Glucose leaves the liver and goes to the muscle. what happens next on the way back to liver

glu--> pyruvate--> alanine

Alanine is here to pickup AA waste

alanine--> liver--> NH2 to the urea cycle --> pyruvate--> glucose--> etc

9

what is missing in gaucher

b-glucocerebrosidase

10

what are gaucher cells

macs with"wrinkled tissue paper" appearance from glucocerebroside accumulation

11

what pathway does glucagon use

↑ glucagon --> ↑ cAMP --> ↑ Protein kinase a --> --> gluconeogenesis

12

how does epinephrine work in the liver

↑ epi--> beta receptor --> ↑ cAMP --> ↑ protein kinase A--> ↑ glycogen phosphorylase kinase --> ↑ glucose

same of glucogon

13

what receptors ↑ protein kinase a

Gi and Gs

14

what does protein kinase a do?

↑ Ca

blocks myosin light chain phosphorylase in smooth muscle

15

what can lead to ↑ protein kinase c

DAG. from Gq

16

so... you wanna make glucose. what energy source gets you from TCA back up the chain

GTP- which comes from the TCA

succinyl coa--> succinate makes GTP

17

What is the power source of anaerobic gycolysis

niacin

18

insulin goes to its TK--> watch pathway leads to growth

RAS/ MAP

19

insulin goes to its TK. what pathway goes to ↑ GLUT 4

PI3K

20

what can riboflavin make

FMN and FAD

21

if you give methotrexate what happens

dihydrofolate is inhibited (usually this makes tetrahydrofolate)

folic acid and dihydrofolate acculumulates

22

blister porphyria is missing what

uroporphyrinogen decarboxylase

23

if you are missing carnitine, what will be wrong

Fat degradation will not work


toxic accumulation in mitochondria

s/s: Weakness, hypotonia
↓ glucose, ketones