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Flashcards in General sciences Deck (24):
1

What does lead directly inhibit

delta aminolevulinic acid

Ferrochelatase

S/s: neurotoxicity, anemia, and ZN in place of FE I'm portoporferin

2

What is the function of IL 10

Inhibits th1

Reduced mhc2

Suppresses apcs

3

This helps package DNA up tightly without joining the histone core

H1

Other Hs are wrapped up in DNA

4

What makes major basic protein

Eos

Is the immune response to helmiths

5

What do basophils contain

Granules

-Heparin
-Histamine
Leukotrienes made on demand

6

What do basophils do

mediate allergic reaction

7

any of a group of biologically active compounds, originally isolated from leukocytes. They are metabolites of arachidonic acid, containing three conjugated double bonds.

Leukotriene

8

This drug is for the cray crays and is the only partial D2 agonist

Aripiprazole

atypical antipsychotic

9

What on ENDOTHELIAL cells allows for chemotaxis

Intercellular adhesion molecule 1

Integrin

10

membrane proteins that maintain
integrity of basolateral membrane by binding
to collagen and laminin in basement membrane

Integrin

11

What does a prostacyclin do

↓ platelet aggregation
↓ vascular tone

12

Periodic acid–Schiff stains?

Gycogen

PaS the sugar

13

Kidney-- annoying stuff that happens to kids

PSGN- nephritic

Minimal change disease

14

What is the function of a proteasome

Degraded proteins

Can degrade viral proteins to express on MHC 1

15

What does a lysosome do

Organelle containing acid

Degrades fatty acid, protein, nucleic acid, and carbs

16

Dysfunction of lysosome is called

Mucopolysaccharidoses

17

When does a ribosome attach to the ER

when the protein it is making is meant for secretion, membranes, etc

ribosome will not go to ER if the protein is meant to stay in the cytosol

18

What is an enhancer (genetics)

Helps increase gene activity

can be located kinda anywhere

NOT a promoter which is 25-75 upstream

19

What is the opposite of an enhancer

a silencer

20

What is GPCR

A large family of 7 transmembrane domaine receptors that activate intracellular 2nd messenger systems

2 pathways: cAMP signalling, and Phosphatidly signalling

21

What happens if you activate Gq a subunit

Phophatidylinositol pathway

Gq a--> activates Phospholipase C--> degraded lipid membranes into DAG and IP3

DAG--> activates Protiein Kinase C

IP3--> releases Ca

22

During catabolism of protein into glutamate (to ultimately make glucose), amino groups are transferred to

a-ketoglutamate

23

Ultimately, what is the end result of the Jak/STAT path

JAK activates the cytoplasmic transcription factor STAT to promote gene transcription

Therefor, growth stuff tends to use this path (GH, Epo, etc)

24

What tissues predominatliy make alkaline phosphotase

Bone and Liver

hepatic y- glatamyl transpeptidase test is not in bone, and helps tell disease between bone and liver apart (if alk phos is elevate)