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Flashcards in U World Assesment 1 Deck (46):
1

Recent trauma, white looking lung (pulm opaciety) with normal sized heart

could be ARDS

2

What is the cause of ARDS

injury to pneumocytes and pulmanry endothilum

3

What does DM nephropathy look like

Mesangial Expansion
Basement membrane thickining
Glomerular Sclerosis

4

Speed of conduction through the heart

Fastest- Perkingie (in ventricles) -> Atria -> Ventricles-> AV node (R atria) -Slowest

Park AT Ventricular AVenue

5

Heart Conduction Pathyway

SA (atria) --> AV (tricuspid)--> Bundle of his--> L/R Bundle Branch --> Perkingie--> Vent. Muscle

6

Tumor most often seen in Paget of bone

Osteosarcoma

"periosteal elevation" or Sun Burst Pattern

7

What do Proteases cleave

Protein tagged with ubiquitin

8

A "Ladder" of DNA on gel electropheisis

Apoptosis- Cleaves DNA into 180 base pairr bits, leading to equal ladder aperence on gel

9

What is pheostigmine

cholinesterase inhibitor

aka increases AcH

Atropine will reverse its effect

10

Side effects of Atropine

Hot as a hare ( increased body temp)
Dry as a bone (dry mouth, skin, etc)
Red as a beet (flushed)
Blind as a bat ( cycloplegia)
Mad as a hatter (AMS)

Jimson weed is drug of abuse that will also lead to this (acts same as atropine)

11

Why does atropine increase body temp

decreased sweating

12

Achondroplasia demonstrates what kind of penetrance

complete penetrance

13

Translocation for Burkitt Lymphoma

t(8:14)

14

CML translocation

t (9:22)

15

ALL translocation

t (12:21)

16

Follicular lymphoma translocation

t (14:18)

17

Which disease shows auer rods

APML

t( 15:17)

18

What does IL 2 do

made by T CELL

Stimulates growth of T, B, NK, Mac cells

19

A calcuim dependant adhesion molecule that binds epithilial cells together

Cadherin

20

Defense Sublimation

Channeling impulse into a sociatly GOOD thiing
*Mature

21

How does ligand binding to a TK receptor work

TK receptor dimerizes and exposes the active site

22

Nasal septum perferation is probably

Substance Abuse most likely cocain mediated by vasoconstriction

23

How long does an Acute Stress disorder go on for to start being called PTSD

ASD is over 3 days, less than 1 month

After 1 month, the symptoms are called PTSD

24

Schizophrenic Symptoms lasting LESS than 6 months is called

Schizophreniform

25

What are the 2 labs that evaluate a pleural effeusion (lights criteria)

Protein (high in exudate/ infection)

LDH (high in transudate/ CHF)

26

Primary Test for Herditary Spherocytosis

Osmotic fraglity

Low OSM--> More hemolysis (vs control)

27

Where does hemolysis in herditary spherocytosis occure

Spleen

Spleen removal will lead to decreased bili gallstones, jaundice, and improved anemia

28

Most likely maliganancy in Myasthenia Gravis

60-70% have hyperplstic thymic tissue

10-20% have Thymoma

29

most likely malignancy for eaton Lamburg

Lung Cancer

30

What kind of gene is RB

RB is tumor supressor

Chromosome 13

31

First line treatment for pheochromocytoma

Phenoxybenzamine - long acting alpha blocker

Beta Blocker alone leads to HTN crisis

32

If a premature baby has a brain bleed, what bleed is it

Germinal Matrix Hemmorrhag

Germinal matrix is part of developing brain, involutes by week 28, very weak and bleds easily

33

Amiodarone Drug Reactions

Class 3 K Blocker

Hypo/Hyper- thyroid
Photosensativity
Pulm Fibrosis

*P450 Inhibitor

34

Why does Aspirin INtolerance Asthma happen

Dysregulation of Arachodonic Acid pathway

Too much AA gets pushed down Leuktriene pathway instead --> Inflamation/asthma

35

What happens to heart rate with nitrates

NItrates venodilate--> decrease preload--> reduces SV--> increases heart rate

36

What does parathyroid hormone do

Increases serum calcium

Decreases erum PO4

37

This is the end organ resistance to PTH
AD condition with short stature and short fingers

Albright Osteodystrophy

Labs show:
Inc Phos, PHT
Dec Ca

38

What is Allelic Heterogeneity

Different Mutations IN THE SAME GENE leading to a similar phenotype

39

What is Polygenic

Mutations at different genes leading to a similar phenotype

40

In Maple Syrup Urine disease, what can pts not break down

Leucine
Valine
IsoLuecine

(I Love Vermont maple syrup)

41

What cell type makes androgen binding protein

Sertoli

Helps maitain high testosterone for sperm making

42

What receptor type does insulin use

Tyrosine Kinase

43

What receptor does Glucagon and Epinephrine use

Gs

44

If you have a PE, what will your PCO2 look like

PE--> V/Q mismatch--> Hypoxemia--> reflex HYPERventalation--> decreased CO2--> Resp Alk

45

What kind of penetrance does neurofibromatosis have

100% Penetrance
Variable Expresivity

46

Is red man syndrome from IgE

NO
It is not an allergic side effcect

Can be prevented by SLOWER infusion rate of vancomycin, which keeps blood histamine lower