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Flashcards in Immunology Deck (19):
1

Type 1 hypersensitivity

IgE
Basophils and mast cells response

ex: allergies

2

Type 2 hypersensitivity

IgG and IgM
Complement

PMN response

ex: Autoimmune hemolytic anemia

3

Type 3 hypersensitivity

Deposition of antibody- antigen complex

PMN response

ex: serum sickness

4

Type 4 hypersensitivity reaction

No humoral Component

T cell and Mac response

ex: contact dermatitis, TB skin test

5

Describe Acute hemolytic transfusion reaction

Given Blood
preformed ANTI- ABO ABs attack
Complement activates and lysis the blood and leads to shock

s/s: fever, hypotension, chest pain, back pain, hemoglobinuria

6

What do eosinophils do

IL5 (from Th2/masts) activates them during parasite infection

Parasite is coated in IgG/E that bind Eos Fc--> eos degranulation of major basic protein

7

How do eos act in a type 1 hypersensitivity

eos synthesize PGs, leukotrienes, cytokines that contribute to late phase type 1 hypersens

8

Eosin means

pink dye

9

Causes of eosinophilia

Neoplasia
Asthma
Allergic
Chronic adrenal insuf
Parasites

10

What is major basic protein

a helminthotoxin

11

What are the steps of Leukocyte Inflammatory accumulation

Margination
Rolling
Activation
Tight adhesion and crawling
Transmitigation

12

What mediates PMN rolling

L-Selectin on PMN
E-Selectin/P-selectin on Endothilial cells

13

How do PMNs do tight adhesion and crawling

CD18 beta 2 integrin binds ICAM-1 on endothilum

14

What mediates PMN Transmitigation

This is how PMN exits the blood via intigrin attachment to platlet endothelial cell adhesion molecule 1 (PECAM-1)

15

What recognizes a stop codon

releasing factor

16

How do antigens become able to be presented on an MHC1

They are Ubiquitinated
Proteasome chews it up
Small enough to present the bits

17

What characterizes anaphylactic shock

↑ Vascular permeability
Bronchoconstirction
Vasodilation

18

How do you treat anaphylactic shock

Step 1- epinephrine (epi pen!)

step2- diphenhydramine

19

What is hereditary angioedema

low C1 inhibitor (cannot turn down complement cascade)--> Angioedema

ACE inhibitors have a rare side effect of angioedema, so you cannot give that o these pts