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Flashcards in Neuro/Immune/MIS MASH! Deck (60):
1

what is the principal stabilizing factor for secondary protein structure

H bonds

so this does alpha and beta sheet formation

2

All volatile anesthesia increases this

-Cerebral blood flow

-Can create the bad effect of ↑ ICP

3

What are some important effects of anesthesia

↑ Cerebral blood flow
Myocardial depression
Hypotension
Resp depression
↓ Renal fx

4

How does anesthesia work

Main: ↑ GABA

Maybe: Hyperpolarize neurons via K channel

5

What makes people sick after chemotherapy

Chemoreceptor trigger zone
Is on the dorsal medulla

6

If you need to treat delirium what do you use

Alwaysfix underlying problem but

haloperidol- typical anti psycotic
Well tolerated at low doses

7

What is the name of vertebral movements

subluxation

8

What part of the spine do people w/ RA tend to have problems with

Cervical spine
May have laxity/ subluxation

9

How does Lamotrigine work/what s/e is concerning

SZ drug

Blocks voltage gated Na channels

s/e: 1% get steven johnson syndrome

10

What is Sertraline

SSRI

11

What is the most common side effect of SSRI

sexual dysfunction

12

What type of drugs are:

Chlorpromazine, fluphenazine

Compare the potency

Low pot: Chlorpromazine. ↑ anti-chol


High pot: Fluphenazine. ↑ EPS

13

This disorder is charachterized by feeling detached from self. Feelings of unrelaity.
Aware

Depersonalization disorder

14

This is an opiod antagonist that helps treat alcohol cravings

Naltrexone

15

What does saltatory conduction mean

Propagation of action potential

latin for hop- hop from node to node

16

What does a left frontal lobe lesion lead to

Apathy
Depression

17

What does a right frontal lobe lesion lead to

Disinhibited behavior

18

What is Picks Disease

Frontotemporal dementia
Loss of frontal lobe

19

Pick disease s/s

Frontal lobe problem
Personality and behavior changes

20

What is transference

It is EXACTLY like displacement except:

displacement: current person

Transference: past person (daddy issue)

21

Friedreich ataxia basics

FXN gene GAA repeat

s/s
-Gait ataxia
-Loss of position/vibration
-Kyphoscoliosis/ foot abnormal
-Hypertrophic cardiomyopathy
-DM

22

What brain problem is usually seen in ADPKD

Berry aneurysm
usually in circle of willis--> SAH

23

What genetic disease has lots of acoustic neurmos

Nf2

chromo 22

24

Gene mutation in neurofibroma 2

nf2 gene (chomo 22) --> protein merlin

*Acustic Neruoma

25

gene mutation in neurofibromo 1

nf1 gene (chromo 17) --> neurofibromin

cafe au lait spots
neurofibroma
lisch nodules

26

What brain involvement is typical for huntigtons

Caudate and putaman loss of neurons

27

What is a quadricep muscle

The front leg muscles

rectus femoris, vast lat, vast med, vast intermed

28

What lab ddx stuff should you see in wilson's

↑ Copper on liver biopsy
↑ Copper in UA

↓ Ceruloplasmin (copper transport)

29

Wilson's gene defect

AR ATP7b defect
Messes up liver processing of copper

30

What is psychodynamic therapy

figure out insight into unresolved issue from childhood

31

WHat is Supportive psychotherapy

Bolsters adaptive defence to help with coping

32

What is the best therapy for specfic phobia

Behavior Therapy - exposure

33

In embryology what gives rise to the glomuli

Metanephric mesoderm (blastema) gives rise to the glomuli

34

What in embryo gives rise to the collecting system (tubes, major/minor calyx, pelvis, urter)

Ureteric bud

35

What is most common muscle injury in rotator cuff

Supraspinatus muscle injury

36

What does supraspinatus do

aBduct

37

What does Anicteric mean

silent or subclinical

38

What is the age of onset for a neuroblastoma

0- 2 years old

s/s: non-rhythmic conjugate eye movements with myoclonus

39

What is neuroblastoma

develops from neuroblasts in the adrenal medulla

usually ↑ N-Myc

"most common extracranial neoplasm in children"

40

What is the rare/dangerous side effect of trazodone

Priapism- aka boner

Traza-BONE

41

How does trazodone work

serotonin modulator - inhibits 5ht reuptake and atags post-snap 5ht

42

What structure does the compression in carpal tunnel

Transverse carpal ligament compresses the median nerve

43

What receptor does uterus relaxation

b2

44

What is another name for/ the deal with global cerebral ischemia

Ischemic- hypoxic encephalopathy

profound cerebral hypoperfusion--> ischemia/ watershed infarcts

45

What is encephalopathy

a broad term to describe anything that messes with the brain

46

What rx is unique and special about carbamazepine

1st line rx for trigeminal neuralgia

in clinic you know it needed sz drug, + that chubby mexican girl ate so many *CARBs*
--> couldn't see the face defect



47

Where is a acoustic schwannoma usually found

cerebello pontine angle

The "swan" princess "bella" lived in the "PONd"

48

What would it look like if an acustic schwanoma got really big

cerabella-pontine CN would be disrupted

CN 5, 7, and 8

49

What does clozapine treat, wheat needs to be monitored

Clozapine= atypical antipsych (d2 antag, variable 5ht).
Cloz= only drug proven in rx-refractory skitso

s/e: agranulocytosis

50

Where do the CN exit skull

C- 1/ cribriform plate
O- 2 optic canal
S3- 3, 4, V1- superior orbital fissure
R- V2- rotundum
O- V3 Foramen Ovale
S- 6- superior orbital fissure
I2- 7, 8- Int. Acoustic meatus
J3- 9, 10, 11 - Jugular foramen
H- 12, hypoglossal canal

51

What os the difference b/t neuroleptic malig and serotonin syndrome

symptoms overlap

SS has hyperreflexia and clonus though

52

What is wrong in Alzheimer's (aka what NT)

↓ AcH in nuc basalis of meynert/hippocampus

(that's why the old alz person gala is in the ach-esterase-i sketch)

53

Ethosuximide blocks t type ca channel. Why does that help

Causes hyperpolarization

54

Why do phenytoin, carbamazepine, and valproic acid help in sz

inhibit high frequency firing of Na--> less able to spread sz

55

What antibiotic can cause 5ht syndrome

Linezolid - has MAOI activity, if used w/ SSRi--> 5ht syndrome

linezolid is- oxazolidinone, binds 50s for gram + only

Other s/e: bone marrow suppression, peripheral neuropathy

56

What is the sketchy for linezolid

Police line at the robbed king tut exhibit

robber left smiley face graffiti, aka 5ht

57

s/s of ETOH withdrawal

Tremor
agitation
anx
delirium/ psychosis
SZ, tachy, palapationa

*VERY similar for benzos

58

s/s of heroin withdrawal

NVD
muscle aches
Dilated pupil
Yawning
Lacrimation

59

How do ADHD stimulants work

↑ NorEpi and Da in prefrontal cortex

60

What kind of drug is citalopram

SSRI