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Flashcards in Random sauce who cares Deck (39):
1

1- recently sick
2- palpable purpura/ arthralgia

Henoch Scholein Purpura - most common vasculitis in children

IgA deposites in blood vessels- Type 3 hypersenstaivty

2

How do you treat someone who overdosed on beta blockers

Glucagon

3

What activates the extrinsic pathway of apoptosis

Fas Receptor

4

What is an important driver in Temporal Arteritis

IL 6

Tocilizumab is vs IL6 and can help

5

What is wrong is collagen type 1 is messed up

Osteogensis imperfecta

type 1= bone

6

What is wrong if Collagen 3 is messed up

Ehlers danlos

7

What is wrong if collagen 4 is messed up

Alport

type 4= makes the floor (basement membrane)

8

What does collagen type 2 make

car-TWO-lage

9

This is a genetic defect in the Helicase enzyme

Bloom Syndrome
BLM gene

10

Bloom syndrome symptoms

↓ Growth
Immunodeficiency
Photosensitive skin rash

Helicase defect

11

What blood supplys the left ventricle

Posterior Descending Artery
in 80-90% of people, this vessel comes from the Right Coronary artery

12

What causes Paroxysmal nocturnal hemoglobinuria

An aquired mutation in myeloid stem cell --> no GPI anchors

No GPI--> No CD55--> complement lysis the RBCs

(Cd55 usually inhibits complement)

13

What metobolic steps require thiamine as a cofactor

Pyruvate Dehydrogenase

a-ketoglutarate dehydrogenase

14

What is winters formula

PaCo2= [1.5*Hco3] + 8 (ish)

15

WHat does calcineurin do

Activates Il2--> promotes T cell growth

16

What is wiskott aldrich syndrome

Triad of eczema
thrombocytopenia
B and T cell immunodeficiency

17

What chemo causes hemoragic cystits and how do you prevent it

Cyclophosphomide casues it
Mesna helps

18

What is at least 1 reason people get methemoglobin

Nitrateexposure
changes Fe 2 and Fe 3

19

What is a red neuron

they are eosiniophilic
Loss of Nissle substance
Happens about 12-24 hours after cerebral insult

20

How long does a glial scar take to form

>2 weeks, usually a month

21

How long does liquefactive necrosis happen

Starts 1 week after brain injury--> lasts ~1 mo

22

______ is the payment structure underlying HMO

Capitation
payor pays a fixed amount to provide any services to their group

23

What are some common mutations for spherocytosis

Spectrin
Ankryin
Band 3
protein 4.2

24

What causes acute intermittent porphyria

deficiency of

uroporphyrinogen I synthase

25

What causes thrombotic thrombotocytopenic purpura

AB vs ADAMS13

ADAMS13 degrades vWF to the proper size

26

in general, how may blasts in marrow do you need to call something acute leukemia

over 20% blasts

27

What are reed sternberg cells positive for

CD 15 and CD 30

28

This presents similar to multiple myeloma but has lots of IgM

Waldenstrom macroglobulinemia

29

This tumor drug prevents microtubule disassembly

Taxanes
ex: paclitaxal

30

What is the treatment for CML from a 9:22

Imatinib / gleevac

31

Chronic rejection of lung transpants is a big problem. WHat does it look like

Affects the small airways causing bronciolitis obliterans

Lymph infiltrates, fibrosis

32

WHats up with common cardinal veins

in embryo these drinind into sinous venousis

they eventually give rise to SVC

33

if you have a "gene problem" and you see that the base pair number vs control is not divisible by 3, what does that mean?

Prolly a frame shift mutation

34

What is a nonsense mutation

introduction of a stop codon

35

what is a missense mutation

Base pair substitution

36

What are the two most important opsonins

IgG
C3b

C3b binds bacteria

37

What does C5a do

PMN chemotaxis

38

What are some things that do PMN chemotaxis

leukotriene b4
c5a
il 8

39

This is when coronary vasodilation allows for blood flow to be reduced in ischemic areas, and it is a bad thing

Coronary steal

Adenosine and dipyridamole can do it