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Flashcards in Rheum Deck (65):
1

What do intigrins do

Enable leuks to exit blood stream
Absent in leukocyte deficiency--
Will have delayed umbilical cord detachment

2

What is the main function if PTH

Increase bone reabsorbtion aka increase ca

Phosphate is decreased in serum (put out in urine)

3

What does pth act on

Osteoblasts, which increase rank, which matures osteoclasts

4

What can block rank and why do you care

Osteoprogesterin blocks rank

When estrogen gets low, osteoprogesterin gets low, clasts over activate, and...

OSTEOPOROSIS occurs

5

Gram negative oxidase positive rod causing itchy rash

Psuedmona
Hot tub folliculitis

6

Blue black deposits on sclera and ear with joint pain

Alkaptonuria

Also urine turns black in the sun

7

What does fibrillin do

Glycoprotein scaffold for elastin

8

What are the typical lab values for osteoporosis

Totally normal ca, phos, and PTH

9

What mediates muscle tone in nervous system

Golgi tendon organ

10

What is linked to drug induced lupus

Drugs metabolized by acetylation
Ex: INH

11

Rhomboid crystals with knee pain

Psueodo gout

Crystal made up of calcium pyro phosphate w/ + bifringence



12

What is the first line treatment for gout

NSAID

13

What drug do you NOT give DURING a gout attack

Uric acid lowering drugs

Ex: xanthine oxidase inhibitor

These PREVENT gout but make active gout worse

14

What do gout needles look like?

Needle shaped
Negative bifringence

15

Remembering the contraction of muscle bands

HIZ shrinkage (these shorten)

A band is Always the same length

16

Problems with umbilical cord detachment and recurrent skin infections w/I puss

Leukocyte adhesion deficiency
AR
No CD18 , no intigrins

17

What is the MOST important factor for osteoporosis

Genetics

18

Proximal muscle weakness
Over expression MHC 1 on sacrolema

Polymyositis

Cd8 infiltration leads to myocyte damage

19

This auto antibody is the most specific for RA

Citralunated peptide

20

A patient with cancer and high serum calcium likely has what elevated?

Parathyroid hormone related protein.

21

Reparative kneeling may lead to what?

Pre patellar bursa

22

What allows the binding of myosin to actin?

Calcium binding to troponin c

23

inhibits neutrophil motility and activity, leading to a net anti-inflammatory effect. This has proven useful in the treatment of acute gout flares.

Colchacine

24

What biopsy is characteristic of polyarteritis nodosa

Multisystem involvement with biopsy showing transmural inflammation of arterial walls with fibrinoid necrosis.

Small and medium vessels.

25

Do psgn and acute rhematic fever usually happen together

No.

If arf is present, most likely the complication will be pancarditis

Mitral stenosis occurs years after original illness

26

Define Parkinson's cogwheel rigidity

Passive movement has ratchet like resistance

27

Joint problems that arise with a myloprofilferative disorder (ie polycythemia vera)

Gout

Myloprofilferative disorder has increased irate production

28

What is seen in mitochondrial myopiathies

Red ragged fibers

29

What is a first line treatment for RA

Methotrexate

30

What are pth levels like in sarcoidosis

Low

Sarcoidosis has vit d activation by macs which increases ca absorption

31

What medicine is structurally similar to pyrophosphate

Bisphosphonate

32

Half of the patients with lambert eaton also have this?

Malignancy
Classically small cell carcinoma

33

What muscle controls external shoulder rotation in the cuff

Infraspinatus

34

Classic autoantibody in polymyositis

Anti jo 1

antibody is directed against the histidyl-tRNA synthetase

Anti nuclear (very easy to confuse with SLE)

35

Does an LP help you determine if there is osteomyolitis

No
Get an MRI

36

The suffix cept for Rx will clue you in for

A receptor molecule

37

The nib in a drug name clues you in for

Kinase inhibitor

38

Anti mitochondria antibody indicates

Primary biliary sclerosis

39

Anti cyclic citrulated antibody is

RA

40

Lab finding for ACTIVE SLE attack

Reduced complement (due to immune complex deposition in organs)

Also weirdly they can have a hard palate ulcer

41

Define a contracture


a condition of shortening and hardening of muscles, tendons, or other tissue, often leading to deformity and rigidity of joints.

Excess matrix metaloproteins

42

What is a t tube

Part of sarcolema
Allows cordoninated contraction

43

What kind of signaling does RANK do

Rank signals NFKB to osteoclasts precursor

44

What is succinylcholine

Fast acting depolerizing Neuromusclual block

45

What kind of block is pancuronium

Non depolerizing block.

46

How do you reverse a nondepolerizing NMH block

Neostigmine

47

Examination showing tenderness in snuff box

Scaphoid fx

Risk of a vascular necrosis

48

Why bone problems do ppis lead to

Ppi decreases stomach acid

Calcium doesn't absorb

Osteoporosis may occure

49

Will the medial lymph system of the leg drain to the popliteal

No.

Medial runs from medial foot to superficial inguinal nodes

50

Where would a lesion be if popliteal and superficial inguinal lymphs are big

Lateral leg

51

Having a rash + muscle weakness is

Dermatomyositis

52

What is the other name for churge straus + what s/s

Eosinophilic Granulomatis with polyangitis

Late onset asthma**
Other "allergy" type stuff
Medium sized vasculitis
Panca (ab vs pmn myeloperoxidase)

53

Osteoporosis can be promoted by what simple drug class

Glucocorticoid
(Also ppi)

54

Abusing anabolic steroids might lead to this skin finding

Acne

55

What is etanercept a decoy for

Tnf a

56

Diffuse muscle pain ontop of giant cell arteritis is known as

Polymyalgia rhematica

57

Which nerve is anterior and lateral on the elbow

Radial

58

What nerve is anterior and medial on the elbow

Median

59

If RA were to affect the spine, which region would it be

Cervical

60

b/c of PUD, a gout pt cannot use NSAID as first line rx. Now what?

colchicine
inhibits microtubule polymerization

61

Besides your abs, what m helps you go from supine to sitting w/o using hands

Psoas major

62

What ligament is damaged in nursemaids elbow

Annular ligament
nursemaid= radial head subluxation

63

What is the halmark of rickets histology

increase in unmineralized osteoid matrix

64

What is the primary vessel messed up for femoral head osteonecrosis

medial circulflex

65

What is Denosumab

RANK L inhibitor