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Flashcards in Enzymes Deck (21):
1

Phospholipase

enzymes that degrade phospholipids into fatty acids

2

desmolase

catalyzes the formation or destruction of carbon-carbon bonds within a molecule.

3

Beta-glucuronidase

Infection of the biliary tract results in release of beta-glucuronidase by injured hepatocytes and bacteria. Contributes to the hydrolysis of bilirubin glucuronides + increases the amount of unconjugated bilirubin in bile.

4

Thyroid peroxidase

Function = oxidation of iodide to iodine + iodination of thyroglobulin tyrosine residues + iodotyrosine coupling reaction that forms T3 and T4.

5

Colipase

Enzyme essential for function of lipase.

6

Phospholipase

enzymes that hydrolyze phospholipids into fatty acids.

7

beta-glucuronidase

Catalyzes breakdown of complex carbohydrates.

8

cytochrome C oxidase

Last enzyme in respiratory electron transport chain of mitochondria. Receives an electron from each of four cytochrome C molecules and transfers them to one oxygen molecule, converting molecular oxygen to two molecules of water.

9

NADPH oxidase

Initiates respiratory burst/intracellular killing. Generates superoxide anion by transferring electrons from NADPH, a reactive free radical.

10

Glutathione peroxidase

Main role is to reduce hydrogen peroxide to water.

11

glutathione reductase

regenerates glutathione

12

glutathione

critical molecule in reducing oxidative stress

13

connection between HMP shunt and glutathione

HMP shunt generates NADPH which is used by glutathione reductase to regenerate glutathione, which is critical for resisting oxidative stress.

14

cofactor required by glutathione peroxidase and reducatse

selenium

15

where does respiratory burst happen?

phagolysosome

16

Liposomal lipase

hydrolyzes triglycerides in lipoproteins, such as those found in chylomicrons and VLDL into 3 fatty acids and one glycerol.

17

LPL cofactor

ApoC2

18

HSL

hormone-sensitive lipase. Intracellular lipase that hydrolyzes esters. *Hydrolyzes stored triglycerides in adipose tissue to free fatty acids.

19

Phosphodiesterase

Any enzyme that breaks a phosphodiester bond

20

Endonuclease

Enzymes that cleave phosphodiester bonds within polynucleotide chain.

21

Erythropoietin MOA

EPO is a glycoprotein hormone that controls erythropoiesis. It is a cytokine for erythrocyte precursors in the bone marrow. Thus ***stimulates proliferation of erythrocyte precursors.