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Flashcards in ID 6 Deck (65):
1

what does E coli produce?

Beta-galactosidase, which breaks down lactose into glucose and galactose.

2

EMB results..

1) lactose fermenters grow as purple/black colonies.
2) e coli grows as a green sheen.

3

meningococci vs gonococci fermentation

- meningococci ferment maltose and lactose
- gonococci ferment glucose

4

meningococci vaccine?

yes but type B not widely available

5

other route of infection of gonorrhea? presentation?

perinatally (causes neonatal conjunctivitis)

6

What is Fitz-Hugh-Curtis caused by?

gonorrhea

7

other presentation of meningococcemia?

gangrene of toes

8

treatment for gonorrhea conjunctivits?

erythromycin to prevent blindness

9

neisseria treatment?

ceftriaxone OR *penicillin G

10

Fitz-Hugh-Curtis syndrome

o Coded character: Chanelle O’conner/seen in women with PID. Ascending, polymicrobial infection of the female genital tract that can involve the endometrium, uterine tube, and/or peritoneal cavity. House is full of adhesions from the roof to a hippo/infection of the liver capsule and “violin string” adhesions of peritoneum to liver. Perihepatitis is a complication that presents with RUQ pain. She’s profusely sweating + has discharge from her vagina/classic triad is fever + abdominal pain + vaginal discharge. Robby Page is licking up the discharge/caused by gonococci.
o Location: Hallweaver’s house on P street.

11

H flu structure

small gram negative coccobacillary rod

12

h flu transmission

aerosols

13

what are h flu infections usually caused by?

nontypeable, unencapsulated strains since the vaccine.

14

"cherry red epiglottitis" on endoscopy?

epiglottitis

15

treatment for h flu mucosal infections (otitis media, conjunctivitis, bronchitis)?

amoxicillin +/- clavulante

16

treatment for h flu meningitis?

ceftriaxone

17

prophylaxis for h flu meningitis?

rifampin

18

when do you give h flu vaccine?

between 2 and 18 months

19

what does h flu vaccine contain?

type b capsular polysaccharide and PRP (polyribosylribitol phosphate)

20

other pertussis toxin?

tracheal cytotoxin

21

Why is pertussis commonly mistaken for viral infection?

Lymphocytic infiltrate resulting from immune response

22

is legionella infectious?

no

23

common sources of legionella

1) AC systems + *hot water tanks

24

how do you detect legionella?

Presence of antigen in urine

25

legionella treatment

macrolide or *quinolone

26

legionnaires presentation

severe pneumonia (unilateral, lobar) + fever + GI + *CNS symptoms

27

legionnaires common in...

smokers + chronic lung disease

28

what is pontiac fever?

mild flu like syndrome caused by legionella

29

other pseudomonas toxin

phospholipase C (degrades cell membrane)

30

pseudomonas capsule...significance

1) mucoid polysaccharide capsule
2) may contribute to chronic pneumonia in CF due to biofilm production

31

pseudomonas treatments

CAMPFIRE
carbapenems
aminoglycosides
monobactams
polymyxins (polymyxin B, colistin)
fluoroquinolone
ThIRd and 4th generation cephalosporins (caftazidime, cefepimp)
Extended-spectrum penicillins (piperacillin, ticarcillin).

32

e coli virulence factor in cystitis and pyelo

fimbriae (P-pili)

33

e coli virulence factor in pneumonia and meningitis?

K capsule

34

EIEC MOA

invades intestinal mucosa and causes necrosis and inflammation

35

EPEC mechanism

no toxin produced. adheres to apical surface, flattens villi, preventing absorption

36

EPEC presentation

diarrhea in kids (P for pediatrics)

37

common sources of EHEC/O157:H7

undercooked meat + *raw leafy vegetables

38

How do you distinguish EHEC from other e coli?

Doesn't ferment sorbitol.

39

other common patient for klebsiella

- diabetics
- abscess in lungs and liver

40

major cause of bloody diarrhea in kids?

campylobacter

41

campy animals

dogs, cats, pigs

42

shigella reservoir

humans only

43

difference between salmonella and shigella in spread

salmonella can disseminate hematogenously; shigella cell to cell, no hematogenous spread

44

salmonella type and lab characteristic

H2S production

45

Salmonella type virulence factor

endotoxin + *Vi capsule

46

salmonella species virulence factor

endotoxin

47

shigella virulence factor

endotoxin + shiga toxin

48

shigella ID50

LOW

49

affect of antibiotics on shigella vs. salmonella

With salmonella and salmonella type, antibiotics will prolong duration. Shorten duration with shigella.

50

immune response to s typhi

monocytes

51

immune response to salmonella species

PMNs in disseminated disease

52

immune response to shigella

primarily PMN infiltration

53

GI presentation of S typhi

constipation followed by diarrhea

54

GI presentation of Salmonella

diarrhea (possibly bloody)

55

S typhi vaccine?

1) oral vaccine contains live attenuated S type
2) IM vaccine contains Vi capsular polysaccharide

56

typhoid fever presentation

*rose spots on abdomen + constipation + abdominal pain + fever

57

typhoid fever treatment

ceftriaxone or fluorquinolone

58

s typhus unique property

carrier state with gallbladder colonization

59

Common sources of salmonella

poultry, eggs, pets, turtles

60

more common cause of salmonella gastroenteritis

non typhoidal salmonella

61

sources of shigella?

4 F's: fingers, flies, food, feces

62

order the severity/toxin production of shigella species

s dysenteriae, s flexneri, s boydii, s sonnei

63

What is the key to pathogenicity of shigella species?

Invasion; organisms that produce little toxin can cause disease due to invasion.

64

vibrio media?

grows in alkaline media

65

vibrio and stomach acidity?

acid labile; requires large inoculum unless host has decreased gastric acidity