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Flashcards in ID 20 Deck (19):
1

IFN-alpha uses

1) Chronic hep B and C
2) Kaposi
3) hairy cell leukemia
4) condyloma acuminatum
5) RCC
6) malignant melanoma

2

IFN-gamma use

CGD

3

Interferons AE's

1) Flu-like symptoms
2) depression
3) neutropenia
4) myopathy

4

ribavirin MOA

inhibits synthesis of guanine nucleotides by competitively inhibiting inosine monophosphate dehydrogenase

5

ribavirin AE's

1) hemolytic anemia
2) severe teratogen

6

Sofosbuvir

Inhibits HCV RNA-dependent RNA polymerase acting as a chain terminator.

7

Sofosbuvir AE's

Fatigue
headache
nausea

8

Sofosbuvir caveat

NEVER use as mono therapy; use for chronic HCV in combination with ribavirin +/- peg interferon alpha

9

simeprevir MOA

HCV protease inhibitor; prevents viral replication

10

simeprevir use

chronic HCV in combination with ledipasvir

11

ledipasvir MOA

NS5A inhibitor

12

simeprevir AE's

1) photosensitivity
2) rash

13

what is disinfection?

reduction of pathogenic organisms to safe levels.

14

what is sterilization?

inactivation of self-propagating biological entities

15

sporicidal infection control techniques?

1) hydrogen peroxide
2) autoclave and iodine/iodophors may be

16

chlorhexidine MOA

denatures proteins + disrupts cell membranes

17

hydrogen peroxide MOA

free radical oxidation

18

iodine and iodophors MOA

halogenation of DNA, RNA, and proteins.

19

clarithromycin why avoid in pregnancy?

embryotoxic