Flashcards in GI Deck (444)
Nontoxic bile acid. Increases bile secretion + decreases cholesterol secretion and absorption.
ursodiol clinical use
PBC + gallstone prevention or dissolution.
inhibits gastric and pancreatic lipase, thus leading to decreased breakdown and absorption of dietary fats.
steatorrhea + decreased absorption of fat-soluble vitamins.
D2 receptor antagonist. Increases resting tone, contractility, LES tone, motility. Does not influence colon transport time.
metoclopramide clinical use
diabetic and postsurgery gastroparesis, antiemetic
digoxin + diabetic agents + SBO or Parkinson disease (due to D2 receptor blockade)
parkinsonian effects, tardive dyskinesia, restlessness, drowsiness, fatigue, depression, diarhea.
serotonin antagonist + decreases vagal stimulation
headache + constipation + QT interval prolongation
agonist at mu-opioid receptors; slows gut motility. Poor CNS penetration (low addictive potential)
constipation + nausea
Sulfasalazine -- MOA, clinical use, SE's
Sally Westcott in a sulfur geiser/sulfasalazine. Pyramid with sulfur geiser on top on right + tree with bark and hailing on it/MOA = combination of sulfapyridine (antibacterial) + 5-aminosalicylic acid (anti-inflammatory). Bacteria on counter throwing lasso around her/activated by colonic bacteria. Rachel in wheelchair next to counter/can cause drug-induced lupus. Riding a dead sperm/toxicity = malaise + nausea + sulfonamide toxicity + reversible oligospermia. /clinical use = UC + Crohn disease.
osmotic laxatives AE's
long-acting somatostatin analog; inhibits secretion of various splanchnic vasodilatory hormones.
nausea, cramps, steatorrhea + increased rick of cholethiasis due to CCK inhibition.
PGE1 analog. increased production and secretion of gastric mucous barrier, decreases acid production.
misoprostol mechanism as abortifacent
Other use of misoprostol.
bismuth, sucralfate MOA
binds to ulcer base, providing physical protection and allowing HCO3- secretion to reestablish pH gradient in the mucous layer.
another use for bismuth, sucralfate
shared AE of all antacids
aluminum hydroxide AE's
constipation + hypophosphatemia + proximal muscle weakness + osteodystrophy + seizures
calcium carbonate AE's
hypercalcemia (milk-alkali syndrome) + rebound acid production
magnesium hydroxide AE's
Harvey milk (sean penn) from movie milk in middle of room giving magnus who’s benchpressing a blowjob: he’s shitting on a towel + IV pole next to him + is being shocked + riding a mini motorcycle/SE’s = diarrhea + hyporeflexia + hypotension + cardiac arrest.
What is a proton pump?
H+/K+ ATPase in stomach parietal cells.