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Flashcards in GI Deck (444)
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1

ursodiol MOA

Nontoxic bile acid. Increases bile secretion + decreases cholesterol secretion and absorption.

2

ursodiol clinical use

PBC + gallstone prevention or dissolution.

3

Orlistat MOA

inhibits gastric and pancreatic lipase, thus leading to decreased breakdown and absorption of dietary fats.

4

Orlistat AE's

steatorrhea + decreased absorption of fat-soluble vitamins.

5

metoclopramide MOA

D2 receptor antagonist. Increases resting tone, contractility, LES tone, motility. Does not influence colon transport time.

6

metoclopramide clinical use

diabetic and postsurgery gastroparesis, antiemetic

7

metoclopramide contraindications

digoxin + diabetic agents + SBO or Parkinson disease (due to D2 receptor blockade)

8

metoclopramide AE's

parkinsonian effects, tardive dyskinesia, restlessness, drowsiness, fatigue, depression, diarhea.

9

ondansetron MOA

serotonin antagonist + decreases vagal stimulation

10

ondansetron AE's

headache + constipation + QT interval prolongation

11

Loperamide MOA

agonist at mu-opioid receptors; slows gut motility. Poor CNS penetration (low addictive potential)

12

loperamide AE's

constipation + nausea

13

Sulfasalazine -- MOA, clinical use, SE's

Sally Westcott in a sulfur geiser/sulfasalazine. Pyramid with sulfur geiser on top on right + tree with bark and hailing on it/MOA = combination of sulfapyridine (antibacterial) + 5-aminosalicylic acid (anti-inflammatory). Bacteria on counter throwing lasso around her/activated by colonic bacteria. Rachel in wheelchair next to counter/can cause drug-induced lupus. Riding a dead sperm/toxicity = malaise + nausea + sulfonamide toxicity + reversible oligospermia. /clinical use = UC + Crohn disease.

14

lactulose

osmotic laxative

15

osmotic laxatives AE's

diarrhea, dehydration.

16

octreotide MOA

long-acting somatostatin analog; inhibits secretion of various splanchnic vasodilatory hormones.

17

Octreotide AE's

nausea, cramps, steatorrhea + increased rick of cholethiasis due to CCK inhibition.

18

misoprostol MOA

PGE1 analog. increased production and secretion of gastric mucous barrier, decreases acid production.

19

misoprostol mechanism as abortifacent

Ripens cervix

20

Other use of misoprostol.

Maintains PDA.

21

misoprostol AE's

diarrhea

22

bismuth, sucralfate MOA

binds to ulcer base, providing physical protection and allowing HCO3- secretion to reestablish pH gradient in the mucous layer.

23

another use for bismuth, sucralfate

travelers' diarrhea.

24

shared AE of all antacids

hypokalemia

25

aluminum hydroxide AE's

constipation + hypophosphatemia + proximal muscle weakness + osteodystrophy + seizures

26

calcium carbonate AE's

hypercalcemia (milk-alkali syndrome) + rebound acid production

27

magnesium hydroxide AE's

Harvey milk (sean penn) from movie milk in middle of room giving magnus who’s benchpressing a blowjob: he’s shitting on a towel + IV pole next to him + is being shocked + riding a mini motorcycle/SE’s = diarrhea + hyporeflexia + hypotension + cardiac arrest.

28

What is a proton pump?

H+/K+ ATPase in stomach parietal cells.

29

ZES treatment

PPI

30

PPI AE's

Nate is banging Heidi on the table + magnus strong man on the table + carson with his ski gear at other end of table/SE’s = increased risk of C. diff infection + decreased serum Mg2+ with long-term use + atrophic gastritis + carcinoid tumors + headaches + GI disturbances. Rest of seats filled with skeletons/associated with osteoporosis and osteoporotic hip fractures (decreases calcium absorption;calcium carbonate requires an acidic environment for proper absorption).