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Flashcards in Neuro X Deck (65)
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1

deficient enzyme in Krabbe disease

galactocerbosidase

2

what builds up in krabbe's?

1) galactocebroside
2) psychosine

3

Krabbe pathophys

galactocerboside + psychosine destroy myelin sheath.

4

findings in Krabbe's

1) peripheral neuropathy
2) developmental delay
3) optic atrophy
4) globoid cells

5

Metachromatic leukodystrophy pathophys

Buildup of sulfatides leads to impaired production and destruction of myelin sheath.

6

Findings in metachromatic leukodystrophy

1) central and peripheral demyelination with ataxia and dementia

7

PML epidemiology

2-4% of AIDS patients

8

What drugs confer increased risk for PML?

1) natalizumab
2) rituximab

9

adrenoleukodystrophy complications

- Long-term coma/death
- adrenal gland crisis

10

adrenoleukodystrophy pathophys

buildup of very-long-chain fatty acids in nervous system + adrenal gland + testes

11

General characteristics of seizures

Synchronized, high-frequency neuronal firing

12

Most common origin of partial seizures

medial temporal lobe

13

partial seizure common scenario

preceded by seizure aura.

14

Simple partial vs. complex partial focal seizures

consciousness intact with simple, impaired in complex

15

status epilepticus cutoff

5 minutes

16

Most common causes of seizures in children...

1) genetic
2) infection (febrile)
3) trauma
4) congenital
5) metabolic

17

Most common causes of seizures in adults...

1) tumor
2) trauma
3) stroke
4) infection

18

Most common causes of seizures in elderly...

1) stroke
2) tumor
3) trauma
4) metabolic
5) infection

19

generalized seizures

1) absence
2) myoclonic
3) tonic-clonic
4) tonic
5) atonic

20

absence seizure characteristics

1) 3 Hz
2) no postictal confusion
3) blank stare

21

tonic clonic (grand mal) presentation

alternating stiffening and movement

22

only headache that's more common in men?

cluster

23

cluster duration

15 min-3 hr; repetitive

24

cluster associated with?

horner syndrome

25

acute cluster treatment

sumatriptan + 100% O2

26

cluster prophylaxis

verapamil

27

typical tension headache duration

Greater than 30 minutes, typically 4-6 hrs. constant.

28

treatment for chronic pain associated with tension headaches?

amitriptyline

29

migraine duration

4-72 hours

30

migraine pathophys

Due to irritation of CN V, meninges, or blood vessels.