Flashcards in hematology oncology part 2 Deck (153)
infection in hereditary spherocytosis?
Parvovirus B19 leading to aplastic crisis
MCV in spherocytosis?
Normal to decreased
Positive osmotic fragility test.
hemolysis type in G6PD?
extravascular and intravascular
Back pain + hemoglobinuria a few days following oxidant stress.
pyruvate kinase deficiency from codebook
• Coded character: Piratte swinging around bathroom + /pyruvate kinase deficiency. Tyrion pissing on the baby/autosomal recessive. Solid, rigid RBC on the floor/defect in pyruvate kinase causes decreased ATP production, leading to rigid RBCs. Baby bleeding out in the sink/presentation = hemolytic anemia in a newborn. /Pyruvate kinase requires all the same cofactors as alpha-ketoacid dehydrogenase (TLCFD).
• Location: BG first floor bathroom
pyruvate kinase pathophys
defect in pyruvate kinase leads to decreased ATP leading to rigid RBCs, leading to extravascular hemolysis
classic pyruvate kinase presentation
hemolytic anemia in a newborn
Don't confuse HbS with HbC
hemolysis type in HbC
HbC on labs (homozygote)
hemoglobin crystals inside RBCs and target cells
One disease smoking is protective for?
etiology of PNH
Acquired mutation in a hematopoietic stem cell.
cancer and PNH?
PNH patients are at increased risk of acute leukemias
Coombs negative hemolytic anemia + pancytopenia + venous thrombosis.
treatment for PNH?
terminal complement inhibitor
sickle cell etiology
point mutation causing replacement of glutamic acid with valine in beta chain
hemolysis type in sickle cell anemia
Extravascular + intravascular hemolysis.
what can precipitate sickling?
2) high altitude
newborns and sickle cell anemia
usually asymptomatic because of increased HbF
epidemiology of sickle cell in AA's
8% of African Americans carry an HbS allele
other thing sickle cell pts are at increased risk for?
Immunoglobulin in warm AIHA?
IgG (warm weather is Great)
when is warm AIHA seen?
1) Chronic anemia such as SLE and CLL
Immunoglobulin in cold AIHA?
IgM and complement (cold weather is Miserable)
when is cold AIHA seen?
1) acute anemia triggered by cold
3) mycoplasma infections
pathophys of cold AIHA and cold
RBC agglutinates cause painful, blue fingers and toes with cold exposure.
Supplied proximally by a branch of the common hepatic (gastroduodenal). This is proximal to the 2nd part of the duodenum. Distal to 2nd part is SMA (inferior pancreaticoduodenal). So inferior pancreaticoduodenal supplies 3rd and 4th sections.