hematology oncology part 2 Flashcards Preview

STEP > hematology oncology part 2 > Flashcards

Flashcards in hematology oncology part 2 Deck (153)
Loading flashcards...
1

infection in hereditary spherocytosis?

Parvovirus B19 leading to aplastic crisis

2

MCV in spherocytosis?

Normal to decreased

3

spherocytosis diagnosis?

Positive osmotic fragility test.

4

hemolysis type in G6PD?

extravascular and intravascular

5

G6PD presentation

Back pain + hemoglobinuria a few days following oxidant stress.

6

pyruvate kinase deficiency from codebook

• Coded character: Piratte swinging around bathroom + /pyruvate kinase deficiency. Tyrion pissing on the baby/autosomal recessive. Solid, rigid RBC on the floor/defect in pyruvate kinase causes decreased ATP production, leading to rigid RBCs. Baby bleeding out in the sink/presentation = hemolytic anemia in a newborn. /Pyruvate kinase requires all the same cofactors as alpha-ketoacid dehydrogenase (TLCFD).
• Location: BG first floor bathroom

7

pyruvate kinase pathophys

defect in pyruvate kinase leads to decreased ATP leading to rigid RBCs, leading to extravascular hemolysis

8

classic pyruvate kinase presentation

hemolytic anemia in a newborn

9

Don't confuse HbS with HbC

ok

10

hemolysis type in HbC

extravascular

11

HbC on labs (homozygote)

hemoglobin crystals inside RBCs and target cells

12

One disease smoking is protective for?

ulcerative colitis

13

etiology of PNH

Acquired mutation in a hematopoietic stem cell.

14

cancer and PNH?

PNH patients are at increased risk of acute leukemias

15

PNH triad

Coombs negative hemolytic anemia + pancytopenia + venous thrombosis.

16

treatment for PNH?

eculizumab

17

eculizumab MOA

terminal complement inhibitor

18

sickle cell etiology

point mutation causing replacement of glutamic acid with valine in beta chain

19

hemolysis type in sickle cell anemia

Extravascular + intravascular hemolysis.

20

what can precipitate sickling?

1) hypoxemia
2) high altitude
3) acidosis
4) dehydration

21

newborns and sickle cell anemia

usually asymptomatic because of increased HbF

22

epidemiology of sickle cell in AA's

8% of African Americans carry an HbS allele

23

other thing sickle cell pts are at increased risk for?

stroke

24

Immunoglobulin in warm AIHA?

IgG (warm weather is Great)

25

when is warm AIHA seen?

1) Chronic anemia such as SLE and CLL
2) alpha-methyldopa

26

Immunoglobulin in cold AIHA?

IgM and complement (cold weather is Miserable)

27

when is cold AIHA seen?

1) acute anemia triggered by cold
2) CLL
3) mycoplasma infections
4) mononucleosis

28

pathophys of cold AIHA and cold

RBC agglutinates cause painful, blue fingers and toes with cold exposure.

29

Duodenum supply

Supplied proximally by a branch of the common hepatic (gastroduodenal). This is proximal to the 2nd part of the duodenum. Distal to 2nd part is SMA (inferior pancreaticoduodenal). So inferior pancreaticoduodenal supplies 3rd and 4th sections.

30

Where is collateral circulation in duodenum?

Superior and inferior pancreaticoduodenal arteries form an anastomotic loop between the celiac trunk and the SMA.