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Flashcards in GN Deck (10):
0

Patient with red dark urine – causes?

1. True hematuria (RBCs)
2. pigmented urine (myoglobin, hemoglobin)

1

Categories of hematuria?

1. Intrarenal (Kidney trauma, renal stones, GN, pyelonephritis, RCC, vascular injury)

2. Extrarenal (Foley trauma, infections, nephrolithiasis, prostate/bladder cancer)

2

RBC casts indicate?

Glomerular origin

3

Nephritis versus nephrosis?

Inflammatory (hematuria, edema, hypertension) verses noninflammatory (no active sediment in the urine)

4

Mechanisms for nephritic findings?

Hematuria – ruptured capillaries of the glomerulus
Proteinuria – altered permeability of the capillary walls
Edema – salt andwater retention
Hypertension – disturbed homeostasis of BO

5

Secondary renal disorders?

1. Lupus (+ANA)
2. Postinfectious GN (+ASO)
3. Hepatitis C/B (cryo- GM)
4. Medium/small vessel vasculitis related (polyarteritis nodosa; Wegner, Chrug-Strauss, microscopic polyangiitis, Henoch-Schonlein purpura)
5. Infective endocarditis related

6

Types of immune mediated injury to the glomeruli? Tx?

1. Complement mediated.
2. Ab-mediated - plasmapheresis
3. ANCA Mediated (pauci-immune) - Steroids/cyclophosphamide

7

Differentiating between the ANCAs?

Wegner's – c-ANCA

P-ANCAs
1. Microscopic polyangiitis - No granulomas
2. Churg-Strauss - Granulomas, asthma, eosinophilia
3. Polyateritis nodosa

8

GNs positive anti-GBM antibodies?

1. no lung involvement - Anti-GBM GN
2. Lung involvement – Goodpasture's

9

Complement mediated GN?

1. Lupus (+ANA)
2. Postinfectious GN (+ASO)
3. Hepatitis C/B (cryo- GM)
4. Infectious endocarditis (+blood culture)
5. RPGN

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