Flashcards in Anaphylaxis Deck (14):
Patient with anaphylaxis – next step?
1. IM epinephrine
2. Corticosteroids and H1/H2 blockers
Swelling lips, periorbital region, face, hands, feet
Like anaphylaxis but not caused by immunologic mechanisms
Anaphylaxis results from?
Immunologic IgE-mediated mechanism
Most common cause of drug related anaphylaxis? Most common cause of food related anaphylaxis?
Anaphylaxis reactions usually occur within?
Clinical Manifestations of anaphylaxis?
Flushing, urticaria, angioedema, diaphoresis
Nasal – sneezing, rhinorrhea, congestion
Throat – hoarseness, strider, laryngeal edema
Breathing – dyspnea, tachypnea, wheezing, Cyanosis
Cardiac – tachycardia, bradycardia, hypotension, arrhythmia
G.I. – nausea/vomiting, diarrhea,
Neuro – dizziness, weakness, syncope, seizures
Erythema multiforme minor?
Target lesions that occurs after HSV or other infection or drugs.
Erythema multiforme major? Findings? Causes?
SJS, involves two or more mucosal surfaces. Petechia, vesicles, bullae, Desquamation of skin
Usually caused by sulfa drugs or NSAIDs
Toxic epidermal necrolysis?
Similar to SJS but greater than 30% epidermal detachment.
Symptoms include: fevers,
Nero – seizures, coma, headache
Joints – arthralgias
Eyes – corneal ulcerations
Cardiac – arrhythmias, pericarditis,
Serum sickness: Time of onset? Symptoms?
Allergic reaction 7-10 days after primary administration (Or 2-4 days after secondary administration) of a drug
Fever, polyarthralgia, urticaria, Lymphadenopathy, glomerulonephritis
Sermon sickness: pathophysiology? Treatment?
Caused by formation of immune new complexes of IgG
Antihistamines, aspirin, NSAIDs
Iodine allergy? Mechanism? Pretreatment? Not related to?
Radiologic contrast allergy.
Caused by hyperosmolar dye causing granulations of mast cells and basophils (not a true allergic reaction)
treat with preemptive diphenhydramine, H2-blockers, and corticosteroids 12 hours before procedure
No evidence that seafood allergy is related to adverse events