Anaphylaxis Flashcards Preview

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Flashcards in Anaphylaxis Deck (14):
0

Patient with anaphylaxis – next step?

1. IM epinephrine
2. Corticosteroids and H1/H2 blockers

1

Angioedema?

Swelling lips, periorbital region, face, hands, feet

2

Anaphylactoid reactions?

Like anaphylaxis but not caused by immunologic mechanisms

3

Anaphylaxis results from?

Immunologic IgE-mediated mechanism

4

Most common cause of drug related anaphylaxis? Most common cause of food related anaphylaxis?

Penicillins; Peanuts

5

Anaphylaxis reactions usually occur within?

5-60 minutes

6

Clinical Manifestations of anaphylaxis?

Flushing, urticaria, angioedema, diaphoresis

Nasal – sneezing, rhinorrhea, congestion
Throat – hoarseness, strider, laryngeal edema
Breathing – dyspnea, tachypnea, wheezing, Cyanosis
Cardiac – tachycardia, bradycardia, hypotension, arrhythmia
G.I. – nausea/vomiting, diarrhea,
Neuro – dizziness, weakness, syncope, seizures

7

Erythema multiforme minor?

Target lesions that occurs after HSV or other infection or drugs.

8

Erythema multiforme major? Findings? Causes?

SJS, involves two or more mucosal surfaces. Petechia, vesicles, bullae, Desquamation of skin

Usually caused by sulfa drugs or NSAIDs

9

Toxic epidermal necrolysis?

Similar to SJS but greater than 30% epidermal detachment.

Symptoms include: fevers,
Nero – seizures, coma, headache
Joints – arthralgias
Eyes – corneal ulcerations
Cardiac – arrhythmias, pericarditis,

10

Serum sickness: Time of onset? Symptoms?

Allergic reaction 7-10 days after primary administration (Or 2-4 days after secondary administration) of a drug

Fever, polyarthralgia, urticaria, Lymphadenopathy, glomerulonephritis



11

Sermon sickness: pathophysiology? Treatment?

Caused by formation of immune new complexes of IgG

Antihistamines, aspirin, NSAIDs

12

Iodine allergy? Mechanism? Pretreatment? Not related to?

Radiologic contrast allergy.

Caused by hyperosmolar dye causing granulations of mast cells and basophils (not a true allergic reaction)

treat with preemptive diphenhydramine, H2-blockers, and corticosteroids 12 hours before procedure

No evidence that seafood allergy is related to adverse events

13

Dilantin (phenytoin) hypersensitivity: Manifests as? Associated with? Mechanism? Treatment?

Skin rash up to TEN. Associated with drug fever that resembles infectious mononucleosis

Not IgE mediated (unclear mechanism)

Treatment is withdrawal of offending agent

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