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Flashcards in MKSAP - Hematology Deck (27):
0

In the absence of inflammation, lower and upper limit of normal ferritin?

In patients with inflammatory disorder, and ferritin lower than 120, likely cause of anemia?

15; 30

Iron deficiency in setting of inflammatory anemia

1

Patient with prolonged bleeding time and mild coagulopathy – diagnosis?

Von Willebrands disease

2

Normal bleeding time, PT, PTT?

<10 minutes, 11–13 seconds, ??

3

Prior to surgery, only need to test for coagulation disorders if?

Positive family history, liver disease, anticoagulation therapy

4

Patient with suspected avascular necrosis/osteonecrosis – test?

1. Plain radiograph
2. If normal X-Ray: MRI (if MRI contraindicated use radionuclide bone scan)

5

Patient with suspected HIT – management? Gold standard for diagnosis?

Stop heparin, start agatroban/lepirudin. Serotonin release assay.

6

Pseudo-thrombocytopenia?

Platelets agglutinate in clumps and are not recognized by blood counters

7

ITP – treatment?

Corticosteroids

8

Patient with previous PE who just finish a course of warfarin. Family history of DVT's – next step?

Thrombophilia screening two weeks after completion of warfarin

9

Hypercalcemia in presence of acute kidney injury suggests?

Most common initial finding these patients?

Multiple Myeloma

Renal failure

10

G6PD deficiency – symptoms? Smear findings? Lab findings?

Jaundice and dark urine (with or without abdominal/back pain)

Bite cells and Heinz bodies

Increased reticulocytes

11

Spherocytes on peripheral blood smear suggest? Test to differentiate?

Hereditary spherocytosis or warm antibody-mediated hemolysis

Direct antigobulin test is positive in warm antibody-based mediated hemolysis

12

Symptoms of macroangiopathic versus microangiopathic hemolytic anemia?

Appears well, no evidence of organ dysfunction, normal platelet count versus opposite

13

Warm antibody-mediated hemolytic anemia – common complication of?

Lymphoid malignancies

14

Mixing studies differentiate between?

Factor deficiency versus presence of inhibitor

15

How to differentiate between DIC and TTP/HUS?

DIC has Elevations in PT, PTT, D-dimer, and low fibrinogen levels

16

Signs of pulmonary hypertension?

Fix splitting of S2, tricuspid regurgitation, right ventricular heave, clear lungs

17

Treatment of acute chest syndrome?

Exchange transfusion

18

Evans syndrome?

Combination of ITP and warm autoimmune hemolytic anemia

19

Patient with antiphospholipid antibody syndrome – criteria for diagnosis? Test to confirm? Length of coagulation?

History of thrombotic event and persistent lupus anticoagulant/IgG anti-cardiolipin/beta-2-glycoprotein one antibodies

Two positive laboratory tests (anti-cardiolipin antibody or lupus inhibitor assay) 12 weeks apart

lifelong anticoagulation

20

Factor V Leiden mutation?

Factor V is resistant to cleavage by protein C

21

Hyper homocystinemia increases risk for?

Venous and arterial thrombosis

22

Monoclonal gammopathy of undetermined significance – characterized by?

M-protein and t deficiency

23

Waldenström's macroglobulinemia involves?

Bone marrow, lymph node, splenic involvement and hyperviscosity syndrome

24

Diagnose CLL with?

Flow cytometry

25

Leukemia with increased numbers of granulocytic cells? Oncogenes?

CML; BCR-ABL

26

Treatment for AML? APL?

Azacitidine;

all-trans-retinoic acid and arsenic trioxide

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