Flashcards in Rheum - Lupus/SLE Deck (14):
Manifestations of SLE?
I'M DAMN SHARP
#Immunoglobulins (anti-dsDNA, anti-Sm, antiphospholipid)
#mucositis (oral ulcers)
#Neurologic (psychosis, seizures, stroke)
#serositis (pleuritis, pericarditis, Libman-saks)
#Hematologic (anemia, leukopenia, thrombocytopenia)
#Renal – diffuse, proliferative, or membranous GN
Antihistamine antibodies suggest?
Hydralazine, procainamide, isoniazid
X-ray of SLE arthritis?
Normal – joint pain without deformation or erosion
Other ocular RA findings?
#Cotton wool spots
How to tell if an acute lupus flare?
Low complement and high anti-dsDNA
Treatment of acute SLE flare?
Hydroxychloroquine and belimumab
Steroids and cyclophosphamide/Mycophenolate
How to determine the severity of lupus nephritis?
Most common cause of death in young lupus patients? Older patients?
APLS syndrome - pathophysiology?
IgG or IgM antibodies (Lupus anticoagulant, anti-Cardiolipin) against negatively charged phospholipids
Lab tests that suggest ALPS?
Clotting + *elevated PTT* and normal PT
APLS may give a false positive on which other test?
RPR and VDRL
Suspect APLS – best initial test? Most specific test for lupus anticoagulant?
Mixing study (if elevated PTT remains elevated, ALPS)
Russell viper venom test
Treatment for ALPS?
#If asymptomatic, no treatment
#if thromboses, treat like DVT