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Flashcards in Heme - Anemia Deck (27):
0

Anemia cutoffs?

Hemoglobin <12 in women

1

Normal reticulocyte count?

1%

2

Most common cause of Fe deficiency anemia in men? Woman?

G.I. bleeding. Menstrual loss

3

Causes of G.I. blood loss?

Upper G.I. tract – esophageal varices, peptic ulcer disease, gastritis, small bowel polyp

Lower G.I. tract – colonic angiodysplasia, colon cancer, IBD, hookworm infestation

4

Causes of uterine blood loss?

Menstruation, uterine fibroids

5

Malabsorption syndromes that can lead to iron deficiency anemia?

Gastrectomy, celiac disease, IBD

6

Symptoms of chronic severe iron deficiency?

1. Cravings for dirt or paint (pica), or ice (pagophagia)
2. Glossitis, cheilosis, koilonychia (spoon nails)
3. Dysphasia due to the esophageal web (Plummer-Vinson syndrome)

7

Microcytic anemia with increased RDW versus normal RDW?

Fe deficiency anemia versus chronic disease, thalassemia

8

Microcytic anemias?

TAILS

Thalassemia
Anemia of chronic disease
Iron deficiency
Lead poisoning
Sideroblastic

9

Normocytic anemias?

#Hemolysis
#anemia of chronic disease
#renal failure
#myelodysplastic syndromes

10

Macrocytic anemia?

#Folate/B12 deficiency
#Drug toxicity (6-MP, azathioprine, hydroxyurea)
#Drugs (zidovudine, phenytoin)
#Chronic liver disease/alcoholism
#hypothyroidism
#MDS

11

Normal absolute reticulocyte count?

50,000 to 70,000

12

Low reticulocyte count versus High reticulocyte count?

Hypoproliferated bone marrow disorders versus blood loss/hemolysis

13

High ferritin levels with?

Chronic inflammatory disease (Rheumatoid arthritis), malignancy, liver injury

14

Fe studies in sideroblastic anemia?

Increased serum iron
Increased serum ferritin

15

Treatment of iron deficiency anemia?

Oral ferrous sulfate 325 mg three times daily for six months

16

Why iron deficiency anemia in pregnancy?

Expanded blood volume

17

FFP cannot be given to patients with?

#Hemophilia A or B
#von Willebrand's disease

18

Causes of sideroblastic anemia?

#Alcohol
#Lead poisoning
#isoniazid
#Vitamin B6 deficiency

19

Ferritin during inflammatory process?

Elevated (acute phase reactant)

20

TIBC?

Unbound sites on transferrin

21

Only type of alpha thalassemia that has an elevated reticulocyte count?

3-gene deletion

22

Patient only drinks goat's milk – dietary deficiency?

Folate deficiency

23

Elevated homocysteine level versus elevated methylmalonic acid signifies?

B12 or folate deficiency versus B12 deficiency

24

Why can be B12 be normal in patients with b12 deficiency?

Transcobalamin (B12 carrier protein) is an acute phase reactant

25

Repletion in B12 or folate can result in?

Hypokalemia (hyperactive marrow packages up potassium lowering serum level)

26

Peripheral smear finding in:
1. Sideroblastic anemia
2. G6PD
3. Sickle cell

1. Basophilic stippling
2. Bite cells
3. Howell-Jolly bodies

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