Flashcards in Syphilis Deck (12):
Chancre usually forms where/when?
At site of entrance within one week to three months of inoculation
Multiple chancre may form if?
Chancroid versus syphilis Versus herpes simplex?
Painful, exudative, with ragged borders and a necrotic base
not erythematous, painless, with rolled borders and clean base
Painful, group vesicles on erythematous base that eventually ulcerate
Late stage syphilis?
Proliferative, obliterative endarteritis
1. Granulomas with coagulated center called gummas
2. In aorta, vasa vasorum involved, leading to necrosis and aneurysmal dilation
3. Neuro: Neurosyphilis, tabes dorsalis, Argyll Robertson pupil
Demyelination of the posterior column with wide based gait and loss of proprioception
Test for syphilis?
1. Fluorescent treponemal antibody absorption (FTA-ABS) or microhemagglutination assay
2. Dark field microscopy
Treatment of Syphilis?
1. Infection for <1 year: single intramuscular injection of penicillin
2. For patients with latent syphilis/cardiac symptoms: three weekly injections penicillin G
3. Neurosyphilis or HIV-infected: IV penicillin for 10 to 14 days
Ways to measure treatment effectiveness?
RPR: Fourfold drop in titers within three months and negative titer after one year
FTA – ABS : positive for life
Common complication after treatment?
If Allergic to penicillin?
Desensitize and then give penicillin
All HIV-infected patients with syphilis should undergo?