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Flashcards in Syphilis Deck (12)
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0
Q

Multiple chancre may form if?

A

HIV positive

1
Q

Chancre usually forms where/when?

A

At site of entrance within one week to three months of inoculation

2
Q

Chancroid versus syphilis Versus herpes simplex?

A

Painful, exudative, with ragged borders and a necrotic base

not erythematous, painless, with rolled borders and clean base

Painful, group vesicles on erythematous base that eventually ulcerate

4
Q

Late stage syphilis?

A

Proliferative, obliterative endarteritis

  1. Granulomas with coagulated center called gummas
  2. In aorta, vasa vasorum involved, leading to necrosis and aneurysmal dilation
  3. Neuro: Neurosyphilis, tabes dorsalis, Argyll Robertson pupil
5
Q

Tabes dorsalis?

A

Demyelination of the posterior column with wide based gait and loss of proprioception

6
Q

Test for syphilis?

A
  1. Fluorescent treponemal antibody absorption (FTA-ABS) or microhemagglutination assay
  2. Dark field microscopy
  3. VDRL
7
Q

Treatment of Syphilis?

A
  1. Infection for <1 year: single intramuscular injection of penicillin
  2. For patients with latent syphilis/cardiac symptoms: three weekly injections penicillin G
  3. Neurosyphilis or HIV-infected: IV penicillin for 10 to 14 days
8
Q

Ways to measure treatment effectiveness?

A

RPR: Fourfold drop in titers within three months and negative titer after one year

FTA – ABS : positive for life

9
Q

Common complication after treatment?

A

Reactive arthritis

10
Q

If Allergic to penicillin?

A

Desensitize and then give penicillin

11
Q

All HIV-infected patients with syphilis should undergo?

A

LP

14
Q

Second stage of syphilis?

A
  1. Pruritic, maculopapular diffuse rash that involves the palms and soles
  2. Condyloma lata
  3. Patchy hair loss
  4. Mucous patches

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