Rate-determining enzymes of metabolic processes Flashcards Preview

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Flashcards in Rate-determining enzymes of metabolic processes Deck (17):
1

Positive and negative regulators of PFK-1

positive --> AMP, f-2-6-BP
negative --> ATP, citrate

2

Positive and negative regulators of F-1,6-BP

positive --> citrate
negative --> AMP, F-2-6-BP

3

Positive and negative regulators of isocitrate dehydrogenase

positive --> ADP,
negative --> ATP, NADH

4

Positive and negative regulators of glycogen synthase

positive --> G-6-P, insulin, cortisol
negative --> epinephrine, glucagon

5

Positive and negative regulators of glycogen phosphorylase

positive --> epinephrine, glucagon, AMP
negative --> G-6-P, insulin, ATP

6

Positive and negative regulators of G6PD

positive --> NADP+
negative --> NADPH

7

Positive and negative regulators of carbamoyl phosphate synthetase II

positive --> ATP
negative --> UTP

8

Positive and negative regulators of glutamine-phosphoribosylpyrophosphate (PRPP) amidotransferase

positive --> AMP, inosine monophosphate (IMP), GMP
negative -->

9

Positive regulators of carbamoyl phosphate synthetase I

positive --> N-acetylglutamate

10

Positive and negative regulators of acetyl-CoA carboxylase (ACC)

positive --> insulin, citrate
negative --> glucagon, palmitoyl-CoA

11

Negative regulators of carnitine acyltransferase I

negative --> malonyl-CoA

12

Positive and negative regulators of HMG-CoA reductase

positive --> insulin, thyroxine
negative --> glucagon, cholesterol

13

rate limiting enzyme of fatty acid synthesis

acetyl-CoA carboxylase (ACC)

14

rate limiting enzyme of ketogenesis

HMG-CoA synthase

15

rate limiting enzyme of cholesterol synthesis

HMG-CoA reductase

16

Positive and negative regulators of pyruvate kinase

positive = F1,6BP
negative = ATP + alanine

17

F-2,6-BP action

Stimulates glycolysis, inhibits gluconeogenesis