Flashcards in 3/10 heme/onc Deck (130)
RBC membrane has what transporter?
Membrane contains chloride- HCO3- antiporter, which allows RBCs to export HCO3- and transport CO2 from the periphery to the lungs for elimination.
varying sizes of RBCs
-dense granules = ADP, calcium
-a granules = vWF, fibrinogen
WBC differential from highest to lowest
Neutrophils Like Making Everything Better.
-granules contain what?
-ALP, collagenase, lysozyme, and lactoferrin.
-azurophilic granules (lysosomes) contain proteinases, acid phosphatase, myeloperoxidase, and β-glucuronidase.
-what are they?
Cell surface marker for macrophage?
-role in type 1 HSR?
-Highly phagocytic for antigen-antibody complexes.
-Produces histaminase and arylsulfatase (helps limit reaction following mast cell degranulation).
Causes of eosinophilia =
Connective tissue diseases
Isolated basophilia found in:
Mast cell degranulation releases:
Histamine, heparin, and eosinophil chemotactic factors.
Universal donor of plasma?
-which blood type
Universal recipient of plasma?
-which blood type?
-anti-A and anti-B antibodies =
-what type of Ab and does it cross the placenta?
-IgM (do not cross placenta)
-IgG (cross placenta)
Treatment: Rho(D) IgG for mother during every pregnancy to prevent initial sensitization of Rh- mother to Rh antigen.
In basic terms, what is coagulation?
Coagulation = soluble fibrinogen converting to insoluble fibrin.
-property of plasma. dont need anything else.
-what hooks onto it?
Antithrombin inhibits activated forms of factors:
II, VII, IX, X, XI, XII.
-1972 + 11 & 12
-binds what? which activates what?
-thrombin activates protein C which inhibits factors 5 & 8.
Effects of thrombin on factor 5 & 8?
-coag. starts slow, but once thrombin made, thrombin goes back and activates factors 8 and 5 which accelerate the pathway. This speeds up coag.
-Protein C and S inactivate factor 8a and 5a. They're the
"brakes" to coag pathway.
Endothelial cell: Weiber-palody body contains:
-vWF in the endothelial cell. These contain vWF & ps-electin.
Ticlopidine and clopidogrel:
-inhibit ADP-induced expression of GpIIb/IIIa.
-irreversibly bind ADP receptor.
-Activates vWF to bind to GpIb.
-Useful for diagnosis: normal platelet aggregation response is not seen in von Willebrand disease.
Acanthocyte (spur cell)
-Liver disease, abetalipoproteinemia (states of cholesterol dysregulation).
BASically, ACiD alcohol is LeThal.
-Anemia of Chronic Disease
-Megaloblastic anemia (also hypersegmented PMNs)