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Flashcards in 4/3 micro Deck (133)
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1

Which cardiac abnormality causes wide & fixed splitting?

ASD

2

In cardiac splitting of S2: which sound comes last?

pulm. valve closing.

3

systolic ejection murmur that inc. in intensity w/standing.

hypertrophic cardiomyopathy

4

abrupt standing: how does this affect cardiac parameters?

-dec. preload.
-dec. afterload.

5

What gets converted to propionyl coa?
-mnemonic?

VOMIT pathway:
-valine
-odd chain FA
-methionine
-isoleucine
-threonine

6

glucocorticoids effect on glycogen in liver:

glycogenesis!
-you would think glycogenolysis, but nope!

7

fenoldopam
-mech?
-ues?

-dopamine D-1 receptor agonist. Dec. BP & inc. natriuesis.
-hypetensive emergencies.

8

Cephalosporins
-What do they not cover?
-Whats the one exception?

LAME
-listeria
-atypicals
-MRSA (except ceftaroline)
-enterococci

9

Only cephalosporin to kill MRSA:

ceftaroline.

10

1st generation cephalos:
-name them?
-coverage?
-mnemonic:

-cefazolin, cephalexin.
-PEcK
-Proteus
-E.coli
-Klebsiella

11

2nd gen cephalos
-coverage?
-mnemonic?

HEN PEcKS
-H. influenzae
-enterobacter
-neisseria
-proteus
-E.coli
-klebsiella
-serratia

12

Ceftriaxone
-which gen. cephalo?
-uses?

-3rd gen.
-meningitis and gonorrhea.

13

Ceftazidime
-which gen. cephalo?
-uses?

-3rd gen.
-Pseudomonas.

14

Cefepime
-which gen. cephalo?
-uses?

-4th gen.
-Pseudomonas.

15

ceftaroline
-which gen. cephalo?
-uses?

-5th gen.
-MRSA.

16

Which cephalos target pseudomonas?
-mnemonic?

CeftazaDIME & cefe"PRIME" = the girl in the tub in the pseudomonas vid was a DIME piece, super PRIME.

17

Cephalos
-tox:

-vitamin K deficiency.
-nephrotoxicity of aminoglycosides.

18

Which antibiotic can cause vitamin K deficiency?

Cephalos

19

Which 2 antibiotic classes together are very nephrotoxic?

Cephalos & aminoglycosides.

20

tryptase
-marker for what?

-released by mast cells.
-marker for mast cell activation.

21

Aztreonam
-is it a lactam?
-sensitive to beta-lactamases?
-can you use it if you're allergic to PCN?

-yes.
-no, not sensitive.
-yes, no cross-reactivity w/PCN.

22

Aztreonam
-mech:

-Prevents peptidoglycan cross-linking by binding to
penicillin-binding protein 3.

23

Aztreonam:
-Synergistic with:

Synergistic with aminoglycosides.

24

Aztreonam:
-target:
-can it target anaerobes?

-gram (-) rods.
-the specific type of PBP it binds to are only found on gram (-) rods.
*can NOT target anaerobes!

25

Carbapenems
-lactam?
-sensitive to beta-lactamases?
-can you use it if you're allergic to PCN?

-yes.
-no, not sensitive.
-no, you cant.

26

Imipenem
-must administer w/what drug?
-why?

-Cilastatin = inhibitor of renal dehydropeptidase I
-To dec. inactivation of drug in renal tubules.

27

Carbapenems
-suffix?

-"penem"

28

Carbapenems
-tox?
-which is safest carbapenem?

-CNS toxicity (seizures).
-meropenem.

29

Vancomycin
-tox:
-mnemonic:

NOT trouble free
-Nephrotoxicity, Ototoxicity, Thrombophlebitis.
-red man syndrome (can largely prevent by pretreatment with antihistamines and slow infusion rate).

30

Linezolid
-mech:

prevent formation of 70S ribosome.