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Final FA review > Immunology > Flashcards

Flashcards in Immunology Deck (30)
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1
Q

VDJ & VJ rearrangement

A
  • VDJ = heavy chain

- VJ = light chain

2
Q

Tdt

A
  • randomly inserts nucleotides into DNA sequence at the junctions of V, D, J segments.
  • only found in lymphoblasts.
  • marker for ALL.
3
Q

Outer cortex of LN

A

B cells & follicles

-brutons agammaglobinemia: hypoplastic cortex.

4
Q

Para-cortex of LN

A

T cells

  • paracortex hyperplasia in viral infections.
  • hypoplastic in diGeorges
  • contains high endothelial venules.
5
Q

Skin above umbilicus: LN drainage

A

axillary LNs

6
Q

Lower rectum to anal canal (above pectinate)

A

Internal iliac LNs

7
Q

Anal canal below pectinate

A

Superficial inguinal LNs

8
Q

Right lymphatic duct

A

Drains right side of body above diaphragm.

9
Q

Spleen marginal zone

A

Where APCs reside and present blood born AGs.

10
Q

Splenectomy: affect on CBC

A

thrombocytosis.

granulocytosis.

11
Q

Thymus:
cortex=
medulla=

A
cortex = immature T cells. (+) selection here.
medulla = mature T cells (MM). (-) selection here.
12
Q

MHC 1

A

HLA-A
HLA-B
HLA-C
-bind TCR & CD8

13
Q

MHC 2

A

HLA-DR
HLA-DP
HLA-DQ
-bind TCR & CD4

14
Q

β2-microglobulin

A

required for expression of MHC1. If it was gone, the
active site of the MHC 1 protein would be fucked up
and not work.

15
Q

Th2 helper Ts

A
  • promote humoral (Ab) immunity (extracellular).
  • release IL-4 and IL-5, which promote class switching.
  • release IL-10 to shut down Th1 cells. So we dont activate too many T cells, only want Th2 active.
16
Q

Th1 helper Ts

A
  • intracellular bugs/viruses = cell mediated immunity.
  • IL-12 causes formation of Th1 from Th0.
  • released IFN-gamma & IL-2
  • IFN-gamma shuts down Th2 cells.
17
Q

Treg

A

FOXP3, CD25, CD3, CD4

-prod anti-infl. cytokines: IL-10 and TGF-β.

18
Q

Brutons agammaglobinemia

A
  • problem w/B cell maturation
  • no mature B cells (unlike CVID)
  • absent/small LNs & tonsils.
  • pan-hypogammaglobinemia.
19
Q

B Cell immunodeficiency mnemonic

A

SBC = shitty B cells

  • Selective IgA deficiency
  • Brutons agammaglobinemia
  • CVID
20
Q

Most common cause of death in DiGeorge?

A

Congenital heart disease

-tetralogy of fallot, truncus arteriosus, etc.

21
Q

Autosomal dominant hyper-IgE syndrome

Job syndrome

A
  • Deficiency of Th17 cells due to STAT3 mutation.
  • impaired recruitment of neutrophils to sites of infection.

-FATED: coarse Facies, cold (noninflamed) staphylococcal Abscesses, retained primary Teeth,  inc. IgE, Dermatologic problems (eczema).

22
Q

Ataxia Telangiectasia

A
  • IgA deficiency (also IgG & IgE).
  • inc. AFP
  • lymphopenia.
23
Q

Chronic transplant rejection (CTR)

Heart

A

atherosclerosis

24
Q

CTR: lungs

A

bronchiolitis obliterans

-terminal bronchioles are inflamed/fibrosed.

25
Q

CTR: liver

A

vanishing bile ducts

26
Q

CTR: kidney

A

vascular fibrosis, glomerulopathy.

27
Q

Side effects of vincristine

A
  • sensory/motor neuropathies.
  • -can have muscle weakness, obtunded reflexes, parasthesias, etc.
  • NO BMS.
28
Q

Filgrastim use:

A
  • enhance neutrophil production.

- aka granulocyte colony-stimulating factor (GCSF)

29
Q

Febuxostat

A
  • xanthine oxidase inhibitor.

- watch out if you’re taking azathioprine/6-MP.

30
Q

Which hepatitis is DNA?

A

Hep B