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Flashcards in Immunology Deck (30):
1

VDJ & VJ rearrangement

-VDJ = heavy chain
-VJ = light chain

2

Tdt

-randomly inserts nucleotides into DNA sequence at the junctions of V, D, J segments.
-only found in lymphoblasts.
-marker for ALL.

3

Outer cortex of LN

B cells & follicles
-brutons agammaglobinemia: hypoplastic cortex.

4

Para-cortex of LN

T cells
-paracortex hyperplasia in viral infections.
-hypoplastic in diGeorges
-contains high endothelial venules.

5

Skin above umbilicus: LN drainage

axillary LNs

6

Lower rectum to anal canal (above pectinate)

Internal iliac LNs

7

Anal canal below pectinate

Superficial inguinal LNs

8

Right lymphatic duct

Drains right side of body above diaphragm.

9

Spleen marginal zone

Where APCs reside and present blood born AGs.

10

Splenectomy: affect on CBC

thrombocytosis.
granulocytosis.

11

Thymus:
cortex=
medulla=

cortex = immature T cells. (+) selection here.
medulla = mature T cells (MM). (-) selection here.

12

MHC 1

HLA-A
HLA-B
HLA-C
-bind TCR & CD8

13

MHC 2

HLA-DR
HLA-DP
HLA-DQ
-bind TCR & CD4

14

β2-microglobulin

required for expression of MHC1. If it was gone, the
active site of the MHC 1 protein would be fucked up
and not work.

15

Th2 helper Ts

-promote humoral (Ab) immunity (extracellular).
-release IL-4 and IL-5, which promote class switching.
-release IL-10 to shut down Th1 cells. So we dont activate too many T cells, only want Th2 active.

16

Th1 helper Ts

-intracellular bugs/viruses = cell mediated immunity.
-IL-12 causes formation of Th1 from Th0.
-released IFN-gamma & IL-2
-IFN-gamma shuts down Th2 cells.

17

Treg

FOXP3, CD25, CD3, CD4
-prod anti-infl. cytokines: IL-10 and TGF-β.

18

Brutons agammaglobinemia

-problem w/B cell maturation
-no mature B cells (unlike CVID)
-absent/small LNs & tonsils.
-pan-hypogammaglobinemia.

19

B Cell immunodeficiency mnemonic

SBC = shitty B cells
-Selective IgA deficiency
-Brutons agammaglobinemia
-CVID

20

Most common cause of death in DiGeorge?

Congenital heart disease
-tetralogy of fallot, truncus arteriosus, etc.

21

Autosomal dominant hyper-IgE syndrome
(Job syndrome)

-Deficiency of Th17 cells due to STAT3 mutation.
-impaired recruitment of neutrophils to sites of infection.

-FATED: coarse Facies, cold (noninflamed) staphylococcal Abscesses, retained primary Teeth,  inc. IgE, Dermatologic problems (eczema).

22

Ataxia Telangiectasia

-IgA deficiency (also IgG & IgE).
-inc. AFP
-lymphopenia.

23

Chronic transplant rejection (CTR)
Heart

atherosclerosis

24

CTR: lungs

bronchiolitis obliterans
-terminal bronchioles are inflamed/fibrosed.

25

CTR: liver

vanishing bile ducts

26

CTR: kidney

vascular fibrosis, glomerulopathy.

27

Side effects of vincristine

-sensory/motor neuropathies.
--can have muscle weakness, obtunded reflexes, parasthesias, etc.
-NO BMS.

28

Filgrastim use:

-enhance neutrophil production.
-aka granulocyte colony-stimulating factor (GCSF)

29

Febuxostat

-xanthine oxidase inhibitor.
-watch out if you're taking azathioprine/6-MP.

30

Which hepatitis is DNA?

Hep B