Immunology Flashcards
1
Q
VDJ & VJ rearrangement
A
- VDJ = heavy chain
- VJ = light chain
2
Q
Tdt
A
- randomly inserts nucleotides into DNA sequence at the junctions of V, D, J segments.
- only found in lymphoblasts.
- marker for ALL.
3
Q
Outer cortex of LN
A
B cells & follicles
-brutons agammaglobinemia: hypoplastic cortex.
4
Q
Para-cortex of LN
A
T cells
- paracortex hyperplasia in viral infections.
- hypoplastic in diGeorges
- contains high endothelial venules.
5
Q
Skin above umbilicus: LN drainage
A
axillary LNs
6
Q
Lower rectum to anal canal (above pectinate)
A
Internal iliac LNs
7
Q
Anal canal below pectinate
A
Superficial inguinal LNs
8
Q
Right lymphatic duct
A
Drains right side of body above diaphragm.
9
Q
Spleen marginal zone
A
Where APCs reside and present blood born AGs.
10
Q
Splenectomy: affect on CBC
A
thrombocytosis.
granulocytosis.
11
Q
Thymus:
cortex=
medulla=
A
cortex = immature T cells. (+) selection here. medulla = mature T cells (MM). (-) selection here.
12
Q
MHC 1
A
HLA-A
HLA-B
HLA-C
-bind TCR & CD8
13
Q
MHC 2
A
HLA-DR
HLA-DP
HLA-DQ
-bind TCR & CD4
14
Q
β2-microglobulin
A
required for expression of MHC1. If it was gone, the
active site of the MHC 1 protein would be fucked up
and not work.
15
Q
Th2 helper Ts
A
- promote humoral (Ab) immunity (extracellular).
- release IL-4 and IL-5, which promote class switching.
- release IL-10 to shut down Th1 cells. So we dont activate too many T cells, only want Th2 active.
