NBDE ANATOMICAL SCIENCES: Blood Flashcards Preview

NBDE PART 1 BIOCHEM/PHYSIOLOGY > NBDE ANATOMICAL SCIENCES: Blood > Flashcards

Flashcards in NBDE ANATOMICAL SCIENCES: Blood Deck (57):
1

where would you find yellow bone marrow in an adult
a. ribs
b. vertebrae
c. cranial bones
d. epiphysis of humerus
e. diaphysis of femur

e. diaphysis of femur

2

the diaphysis is the _ part of the bone

long shaft

3

yellow marrow is found in the hollow center of the diaphysis (long shaft of bone) known as the ____

medullary cavity

4

are bones solid structures

no

5

cavities in the cranial bones, vertebrae, ribs, sternum, and the ends of long bones contain

red bone marrow

6

red/yellow bone marrow produces blood tissue, RBC, WBC, thrombocytes

red bone marrow = hemopoiesis

7

hemocytoblasts in red bone marrow are

multipotent stem cells = give rise to all formed elements in blood

8

progenitor cells are

commited cells formed by hemoctyoblasts

9

_ develop from proerythroblasts

erythrocytes

10

_ develop from megakaryocytes

platelets

11

when a child is _ years of age, yellow bone marrow appears in the distal bones of the ___

7
limbs

12

the yellow bone marrow begins to form in distal limb bones and as the kid becomes an adult the yellow marrow replaces the red marrow moving__

proximally

13

by the time you are an adult, the red bone marrow is restricted to which bones

skull, vertebrae, thoracic cage, girdle bones, and the head of the humerus and femur.

14

at birth all bone marrow is red/yellow

red

15

which are agranulocytes:
basophil/eosinophil/lymphocyte/monocyte/ neutrophils/macrophages

lymphocytes and monocytes
macrophages

16

which have a kidney shaped nucleus?
basophil/eosinophil/lymphocyte/monocyte/ neutrophils/macrophages

monocytes

17

which have a round nucleus with little cytoplasm
basophil/eosinophil/lymphocyte/monocyte/ neutrophils/macrophages

lymphocytes

18

which have lobed nucleus
basophil/eosinophil/lymphocyte/monocyte/ neutrophils/macrophages

neutrophils and eosinophils

19

1. the granulocytes are
2. the agranulocytes are?

1. BEN - basophil, eosinophil, neutrophils
2. MLL: monocytes, macrophages, lymphocytes

20

which have red/yellow granules
basophil, eosinophil, neutrophils

eosinophils

21

which have purple granules
basophil, eosinophil, neutrophils

basophils

22

basophils release (3)

histamine, heparin, and serotonin

23

do we have more platelets or erythrocytes

erythrocytes (5 million)
platelets 150,000-300,000

24

absolute neutrophil count measures cells per microliter. a risk of infection increases dramatically with a reading of

25

the average life span of RBC

120 days

26

differentiation stages of erythroblast?

hemocytoblast --> common myeloid progenitor -->unipotent stem cell --> proerythroblast -->basophilic erythroblast --> polychromatophilic erythroblast --> normoblast --> reticulocyte --> erythrocyte

27

principal function of RBC

transport oxygen and CO2

28

in the lungs Hg is called_
in the tissues Hg is called_

oxyhemoglobin
carbaminohemoglobin

29

70% of CO2 is transported by the __

blood plasma as bicarb ions

30

the portion of RBC in blood is called

hematocrit (46% males and 40% females)

31

the PRECURSOR CELL in the red bone marrow that gives rise to ALL of the formed elements of the blood

hematocytoblast = pluripotent stem cells

32

hematocytoblast give rise to various

multipotent progenitor cells (aka colony forming cells)

33

granulocyte colony stimulating factor (G-CSF) is the hormone that

stimulates precursor cells in bone marrow to differentiate into WBC

34

sickle cell anemia is autosomal

recessive blood disorder

35

the sickle cells block

blood flow by getting stuck in bv

36

what has been mutated in sickle cell

hydrophilic glutamic acid (polar) is substituted with hydrophobic valine (to remember which substituted which remember E ==> V are the amino acids and V looks like the sickle cell therefore that is what has replaced the original E (glutamate)

37

1. genetic deficiency of glucose-6-phosphate dehydrogenase (G6PD) = hemolytic crisis, secondary to decreased _
2. induced by

NADPH
sulfa drugs, oxidants and fava beans

38

formed elements are

RBC, WBC, Platelets

39

blood is _% of body weight
how many liters?
temperature?

8%
4-6L
38C

40

blood is made of _ and _

plasma and formed elements

41

plasma makes up _% of blood and formed elements makes up _%

plasma (55%)
formed elements (45%)

42

which do we have more of: leukocytes/platelets/RBC
put in order

RBC (4-6million)>Platelets(150-300 thousand) > leukocytes (5-10thousand)

43

plasma is mostly _ by weight

water 91%

44

other contents of plasma

91% water, 7% proteins, 2% other solutes

45

serum is plasma without

fibrinogen (clotting factors)

46

platelets are best described as:
a. megakaryocytes
b. agranulocytes
c. lymphoid cells
d. cytoplasmic fragments

cytoplasmic fragments

47

platelets are fragments of large bone marrow cells called

megakaryocytes

48

platelets are minute, irregularly shaped, disc like cytoplasmic bodies found I blood plasma that promote blood clotting. DO they have
a. a definite nucleus
b. DNA
c. Hg

no definite nucleus
no DNA
no hemoglobin

49

life span of platelets

7-10 days

50

platelets are removed by

spleen and liver

51

Thrombopoietin

hormone made by kidney and liver. stimulates precursor cells in bone marrow to differentiate into megakaryocytes -==> platelets

52

platelets stop blood loss by forming a

platelet plug

53

platelet plug begins to form when platelets are exposed to a

rough surface

54

platelets contain many

secretory vesicles (granules) which promote clotting

55

when platelets adhere to collagen they release

ADP and other chemicals = makes the surface sticky so we can form the plug

56

Thromboxane A2 (TXA2) is produced by __ they stimulate _

activated platelets
activation of new platelets and increase platelet aggregation

57

Prostacyclin (PGI2) __ platelet aggregation and causes vaso__

decreases, vasodilation