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Flashcards in 3/16 Deck (23):
1

What syndrome consists of immunodeficiency, albinism, and neurologic defects?

Chediak-Higashi syndrome (AR inheritance)

2

What is the epidermal lesion that looks brown and "stuck on"?

Seborrheic keratosis

3

Ataxia, dysarthria, and loss of proprioception and vibration sense are common to what two pathologies?

Friedreich ataxia, vit E def

4

What nerve exits the pons at the level of the middle cerebellar peduncles?

Trigeminal

5

Hydroxyurea MoA? Use?

Increase HbF production for HbS patients

6

Gardos channel blocker MoA? Use?

Calcium-dependent potassium channel blocker, prevents K and water efflux, reducing dehydration of erythrocytes in HbS patients

7

What is the progression of salicylate poisoning acid/base disorders?

Early: resp alk
Hours later: mixed resp alk/meto acid
Late: meto acid

8

Fenoldopam MoA? For?

selective DA-1 receptor agonist, causes arteriolar dilation and natriuresis

For hypertensive emergency

9

How do drugs like oxybutynin help with detrusor instability?

Anticholinergic effect on M3 receptors, decreases IP3 and Ca release, relaxes smooth muscle

10

How does propranolol help with thyroid storm?

Reduce sympathetic outflow (HR and anxiety), and decrease peripheral conversion of T4 to T3

11

What infection can cause Guillain-Barre?

Campylobacter jejuni

12

Lack of vas deferens and respiratory infections indicate what disease? Test?

CF, test sweat chloride level

13

Giemsa stain for what?

Gee Rick, try borrowing plasma...chlamydia!

Rickettsia
Trypanosomes
Borrelia
Plasmodium
Chlamydia

14

PAS stains for?

PAS the sugar! And the whip!

Whipple's disease
Tropheryma whipplei

15

Ziehl Neelsen stains for?

Nocardia, mycobacterium

16

India ink stains for?

Cryptococcus neoformans

17

Silver stain for?

Legionella, H. pylori, fungi

18

What are the two commonly used aldosterone antagonists?

Spironolactone
Eplerenone

19

Where is the hemochromatosis gene located?

HLA-H (HFE) is located on the short arm of chromosome 6, affects iron absorption

20

Which muscle and/or nerve defect is associated with a winged scapula?

Serratus anterior, long thoracic nerve

21

What strain of E. coli is unable to ferment sorbitol and does not produce glucuronidase?

EHEC O157:H7, which produces Shiga-like toxin which inhibits protein synthesis

22

What short acting hypnotic agent has less potential for tolerance/addiction, withdrawal, sz, muscle relaxation as compared to benzos?

Zoldipem

23

Which abx binds to D-alanyl-D-alanine of cell wall peptide precursors, preventing peptidoglycan formation?

Vancomycin