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Flashcards in 3/25 - UW 23 Deck (45)
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1

Lesion in what part of the brain would lead to a complete contralateral sensory loss?

Thalamic VPL and VPM nuclei

2

How big are lacunar infarcts?

Small, approx 5mm

3

What are two primary causes of lacunar infarcts?

Lipohyalinosis and Microatheromas

4

Oligodendrocyte apoptosis is characteristic of what pathology?

MS

5

What is the gross appearance of MS lesions?

Pink patches in white matter tracts, NOT cavities

6

In what organ does Renin act to convert Angiotensinogen to Angiotensin I?

Liver

7

What are the primary routes of HCV transmission?

Inoculation or Blood transfusions (not so much sexual)

8

Where is the IF-B12 complex absorbed?

Terminal ileum

9

How do OCP prevent pregnancy?

Suppression of FSH and LH secretion from anterior pituitary

10

What enzyme converts heme to biliverdin?

Heme oxygenase

11

How is bilirubin transported to the liver?

Bound to albumin

12

How is bilirubin (unconjugated) converted to bilirubin glucuronide (conjugated)?

By UGT (UDP glucuronyl transferase) in the liver

13

In what disease is UGT deficient in the liver?

Crigler-Najjar

14

What is the effect of 2,3-BPG on Hgb oxygen affinity?

Decrease, shifting curve to the right

15

What type of Hgb doesn't bind to 2,3-BPG?

HbF

16

What kind of change in FSH levels are seen in menopause?

Increase, due to decreased estrogen inhibition

17

What are the major risk factors for esophageal squamous cell carcinoma?

Alcohol, tobacco, foods with N-nitroso compounds (e.g. betel nuts...?)

18

What are the major risk factors for esophageal adenocarcinoma?

Barrett's esophagus, GERD, obesity, tobacco

19

Why would mannitol cause pulmonary edema?

Because it increases intravascular and intratubular volume. Increased IV volume increases hydrostatic pressure, which may leak into the lungs. I guess.

20

Aside from pulmonary edema, what are some other risks of mannitol over-treatment?

Interstitial volume depletion and hypernatremia, Plasma volume expansion and hyponatremia with metabolic acidosis and hyperkalemia

21

When would you see coagulative necrosis?

After ischemic injury, except in the brain

22

When and where do you see liquefactive necrosis?

Focal bacterial infx (with leukocyte involvement) and CNS infarcts

23

When do you see fat necrosis?

Acute pancreatitis, due to lipase release.

24

With what type of necrosis can you see saponification?

Fat necrosis, when lipase-digested fatty acids combine with calcium. In acute pancreatitis

25

When do you see caseous necrosis?

Tuberculous infx

26

Increased bleeding time with no other abnormalities suggests what disease?

von Willebrand's disease

27

What clotting factor does DDAVP increase the production of? From where?

vWF, from endothelial cells

28

Association: DDAVP in bleeding problem...disease??

von Willebrand's disease or hemophilia A

29

What clotting factor does vWF help to stabilize?

Factor VIII

30

What is contained in the lamellar bodies of type II pneumocytes?

Surfactant