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Flashcards in Cytokines Deck (23):
1

What does IL-1 do?

Pyrogenic, inflammatory

2

Which IL causes fever? What secretes it?

IL-1 from macrophages

3

Which IL stimulates T cells? What secretes it?

IL-2 from T cells themselves

4

What does IL-2 do?

Stimulates all T cells

5

What does IL-3 do?

Stimulates bone marrow

6

Which IL stimulates growth and differentiation of bone marrow? What secretes it?

IL-3 from T cells, functions like GM-CSF (granulocyte macrophage colony stimulating factor)

7

What does IL-4 do?

Stimulates IgE production (and IgG)

8

Which IL stimulates IgE production? What secretes it?

IL-4 from Th2 cells

9

What does IL-5 do?

IgA, Eosinophils

10

Which IL stimulates IgA production? What secretes it?

IL-5 from Th2 cells

11

What does IL-6 do?

Pyrogenic

12

What does IL-8 do?

Neutrophil chemotaxis

13

What does IL-12 do?

Differentiation into Th1 cells, activate NK cells

14

What does TNF-a do?

Mediates septic shock

15

Which IL is a major neutrophil chemotactic factor?

IL-8

16

Which cytokines are secreted by macrophages?

IL-1, IL-6, IL-8, IL-12, TNF-a

17

Which cytokines are secreted by all T cells?

IL-2, IL-3

18

What does IFN-y do?

Activates macrophages and Th1 cells. Suppresses Th2 cells.

19

What does IL-10 do?

Modulates inflammatory response

20

Which cytokines are secreted by Th2 cells?

IL-4, IL-5, IL-10, IL-13

21

Which cytokine inhibits Th2 cells?

IFN-y from Th1

22

Which cytokine is secreted by Th1 cells?

IFN-y

23

Which cytokines inhibit Th1 cells?

IL-4 and IL-10 from Th2