Cytokines Flashcards
(23 cards)
What does IL-1 do?
Pyrogenic, inflammatory
Which IL causes fever? What secretes it?
IL-1 from macrophages
Which IL stimulates T cells? What secretes it?
IL-2 from T cells themselves
What does IL-2 do?
Stimulates all T cells
What does IL-3 do?
Stimulates bone marrow
Which IL stimulates growth and differentiation of bone marrow? What secretes it?
IL-3 from T cells, functions like GM-CSF (granulocyte macrophage colony stimulating factor)
What does IL-4 do?
Stimulates IgE production (and IgG)
Which IL stimulates IgE production? What secretes it?
IL-4 from Th2 cells
What does IL-5 do?
IgA, Eosinophils
Which IL stimulates IgA production? What secretes it?
IL-5 from Th2 cells
What does IL-6 do?
Pyrogenic
What does IL-8 do?
Neutrophil chemotaxis
What does IL-12 do?
Differentiation into Th1 cells, activate NK cells
What does TNF-a do?
Mediates septic shock
Which IL is a major neutrophil chemotactic factor?
IL-8
Which cytokines are secreted by macrophages?
IL-1, IL-6, IL-8, IL-12, TNF-a
Which cytokines are secreted by all T cells?
IL-2, IL-3
What does IFN-y do?
Activates macrophages and Th1 cells. Suppresses Th2 cells.
What does IL-10 do?
Modulates inflammatory response
Which cytokines are secreted by Th2 cells?
IL-4, IL-5, IL-10, IL-13
Which cytokine inhibits Th2 cells?
IFN-y from Th1
Which cytokine is secreted by Th1 cells?
IFN-y
Which cytokines inhibit Th1 cells?
IL-4 and IL-10 from Th2
