Flashcards in 3/22 - UW 18 Deck (34):
What are the two acid buffers used to trap H+ in the renal tubular lumen?
HPO4 and NH3
What maternal disease is associated with fetal Caudal Regression Syndrome?
Maternal overdose of what vitamin causes fetal sx similar to DiGeorge syndrome?
Which of the 5 glucose transporters (GLUT) are responsive to insulin?
GLUT 4 (muscles cells and adipocytes)
How do Eosinophils defend against parasitic infxn?
Ab dependent cellular cytotoxicity (ADCC), with IgE
What ligament is displaced in a "nursemaid's elbow"?
What happens to the endometrial cells upon withdrawal of progesterone?
Apoptosis (not atrophy)
Straddle injuries are associated with anterior or posterior urethral
What color is hemosiderin?
Golden yellow brown
What do you give for absence sz?
Ethosuximide or Sodium valproate
What are the most feared, but uncommon side effects of Carbamazepine?
Displaced lens in a child (3-10 years) = ??
Homocystinuria looks like...?
Ectopia lentis, marfanoid habitus, osteoporosis, thromboembolic episodes
What vitamin to give homocytinuria patients?
Which 2 enzymes in the heme biosynthesis pathway are sensitive to lead inhibition?
d-ALAD and ferrochelatase
What infection presents with flu-like prodrome followed by neurologic syndrome (agitation, disorientation, pharyngospasm, photophobia)?
Rabies encephalitis (Rhabdoviridae)
What receptor does CMV bind to?
What receptor does EBV bind to?
What receptor does HIV bind to?
CD4 and CXCR4/CCR5
What receptor does Rabies bind to?
Nicotinic ACh receptor
What receptor does rhinovirus bind to?
What promoter region resides 25 nucleotides upstream from the target gene?
What promoter region resides 70-80 nucleotides upstream from the target gene?
What are the two COMT blockers?
Entacapone and tolcapone, blocking catecholamine metabolism
How does COMT blocker improve levodopa activity?
Decreasing peripheral methylation
What are the major side effects of metformin?
What labs should you check when administering metformin?
What type of cardiotoxicity from anthracyclines?
What should you give for doxorubicin (anthracycline) cardiomyopathy?
Dexrazoxane (iron-chelating agent that decrases O2 free radical formation)
Proton pump inhibitor
Histamine H2 receptor blocker
What are bony prominences at the costochondral junctions and bowed legs suggestive of?
Vit. D def
What changes in bone structure are seen in vit D def?
Unmineralized osteoid matrix accumulation