Flashcards in 3/23 - UW 20 Deck (37):
How do tumor cells mediate detachment from surrounding cells?
Down-regulation of E-cadherins
What is the partial mu opioid antagonist?
What are Auer Rods characteristic of?
Acute myelogenous leukemia (AML)
What genetic abnormality causes Acute Promyelocytic Leukemia (M3 variant of AML)?
What neoplasm is associated with t(8;15)?
What neoplasm is associated with t(11;14)?
Mantle Cell Lymphoma (B cell malignancy)
What neoplasm is associated with a deletion of 13q?
Chronic Lymphocytic Leukemia (CLL)
What diuretic causes hypoK, hypoMg, hypoCa, and ototoxicity?
What diuretic causes hypoK, hypoNa, hypERcalcemia, and hyperuricemia?
What brain tumor is benign, slow growing, arising from the arachnoid villi?
What brain tumor characteristically show Psammoma bodies?
mu receptor MOA?
GPCR activation of potassium efflux
What do you give Protamine for?
What chemical is in rodenticides (rat poison)?
Brodifacoum (4-hydroxycoumarin derivative)
What to give for brodifacoum toxicity?
Fresh frozen plasma and vit K
Where is a PDA heard best?
Left infraclavicular region
In what pathway is acetyl-CoA carboxylase the rate-limiting step?
Fatty acid synthesis
What does glycogen phosphorylase do?
Mediates glycogenolysis by removing single glucose residues from a-1,3-linkages
Deficient production of ketone bodies in starvation is likely due to what enzyme deficiency?
What is the most common cause of fetal hydronephrosis?
Inadequate canalization of the ureteropelvic junction in the metanephros
How does cirrhosis lead to spider angiomas?
Transamination of Alanine's amino group to a-Ketoglutarate produces what two products?
Pyruvate and Glutamate
Polyene antifungals MOA?
Bind ergosterol molecules in fungal cell membranes, creating pores leading to lysis
Inhibit ergosterol SYNTHESIS
Echinocandins ("-fungin") MOA?
Inhibit glucan synthesis (fungal cell wall component)
Flucytosine antifungal MOA?
Converted to 5-fluorouracil and interferes with RNA and protein synthesis
Triad of congenital rubella?
Cataracts, sensorineural deafness, PDA
What type of vax to prevent congenital rubella?
Live attenuated virus vax in NON-pregnant women
What is the drug maintenance dose equation?
MD = Cpss x CL/bioavailability
What is the loading dose equation?
LD = Vd x Cpss/bioavailability
What is the drug half life equation?
t1/2 = Vd x 0.7/CL
What function does N-acetylcysteine serve in CF?
Mucolytic agent that cleaves disulfide bonds in mucosal glycoproteins, loosening sputum
Which vinca alkaloid causes the most neurotoxocity?
In what cell cycle phase do vinca alkaloids halt tumor cells?
What enzyme is lacking in Alkaptonuria?
Conversion of tyrosine to what product is deficient in Alkaptonuria?