3/23 - UW 20

Question 1

How do tumor cells mediate detachment from surrounding cells?

Answer 1

Down-regulation of E-cadherins

Question 2

What is the partial mu opioid antagonist?

Answer 2

Pentazocine

Question 3

What are Auer Rods characteristic of?

Answer 3

Acute myelogenous leukemia (AML)

Question 4

What genetic abnormality causes Acute Promyelocytic Leukemia (M3 variant of AML)?

Answer 4

t(15;17)

Question 5

What neoplasm is associated with t(8;15)?

Answer 5

Burkitt Lymphoma

Question 6

What neoplasm is associated with t(11;14)?

Answer 6

Mantle Cell Lymphoma (B cell malignancy)

Question 7

What neoplasm is associated with a deletion of 13q?

Answer 7

Chronic Lymphocytic Leukemia (CLL)

Question 8

What diuretic causes hypoK, hypoMg, hypoCa, and ototoxicity?

Answer 8

Loop diuretics

Question 9

What diuretic causes hypoK, hypoNa, hypERcalcemia, and hyperuricemia?

Answer 9

Thiazides

Question 10

What brain tumor is benign, slow growing, arising from the arachnoid villi?

Answer 10

Meningioma

Question 11

What brain tumor characteristically show Psammoma bodies?

Answer 11

Meningioma

Question 12

mu receptor MOA?

Answer 12

GPCR activation of potassium efflux

Question 13

What do you give Protamine for?

Answer 13

Heparin overdose

Question 14

What chemical is in rodenticides (rat poison)?

Answer 14

Brodifacoum (4-hydroxycoumarin derivative)

Question 15

What to give for brodifacoum toxicity?

Answer 15

Fresh frozen plasma and vit K

Question 16

Where is a PDA heard best?

Answer 16

Left infraclavicular region

Question 17

In what pathway is acetyl-CoA carboxylase the rate-limiting step?

Answer 17

Fatty acid synthesis

Question 18

What does glycogen phosphorylase do?

Answer 18

Mediates glycogenolysis by removing single glucose residues from a-1,3-linkages

Question 19

Deficient production of ketone bodies in starvation is likely due to what enzyme deficiency?

Answer 19

Acyl-CoA dehydrogenase

Question 20

What is the most common cause of fetal hydronephrosis?

Answer 20

Inadequate canalization of the ureteropelvic junction in the metanephros

Question 21

How does cirrhosis lead to spider angiomas?

Answer 21

Hyperestrinism

Question 22

Transamination of Alanine’s amino group to a-Ketoglutarate produces what two products?

Answer 22

Pyruvate and Glutamate

Question 23

Polyene antifungals MOA?

Answer 23

Bind ergosterol molecules in fungal cell membranes, creating pores leading to lysis

Question 24

Triazoles MOA?

Answer 24

Inhibit ergosterol SYNTHESIS

Question 25

Echinocandins ("-fungin") MOA?

Answer 25

Inhibit glucan synthesis (fungal cell wall component)

Question 26

Flucytosine antifungal MOA?

Answer 26

Converted to 5-fluorouracil and interferes with RNA and protein synthesis

Question 27

Triad of congenital rubella?

Answer 27

Cataracts, sensorineural deafness, PDA

Question 28

What type of vax to prevent congenital rubella?

Answer 28

Live attenuated virus vax in NON-pregnant women

Question 29

What is the drug maintenance dose equation?

Answer 29

MD = Cpss x CL/bioavailability

Question 30

What is the loading dose equation?

Answer 30

LD = Vd x Cpss/bioavailability

Question 31

What is the drug half life equation?

Answer 31

t1/2 = Vd x 0.7/CL

Question 32

What function does N-acetylcysteine serve in CF?

Answer 32

Mucolytic agent that cleaves disulfide bonds in mucosal glycoproteins, loosening sputum

Question 33

Which vinca alkaloid causes the most neurotoxocity?

Answer 33

Vincristine

Question 34

In what cell cycle phase do vinca alkaloids halt tumor cells?

Answer 34

M phase

Question 35

What enzyme is lacking in Alkaptonuria?

Answer 35

Homogentisate oxidase

Question 36

Conversion of tyrosine to what product is deficient in Alkaptonuria?

Answer 36

Fumarate

Question 37

Exposure to what substance will result in eggshell calcification of hilar nodes and birefringent silica particles surrounded by fibrous tissue?

Answer 37

Silica