3/23 - UW 20 Flashcards Preview

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Flashcards in 3/23 - UW 20 Deck (37):
1

How do tumor cells mediate detachment from surrounding cells?

Down-regulation of E-cadherins

2

What is the partial mu opioid antagonist?

Pentazocine

3

What are Auer Rods characteristic of?

Acute myelogenous leukemia (AML)

4

What genetic abnormality causes Acute Promyelocytic Leukemia (M3 variant of AML)?

t(15;17)

5

What neoplasm is associated with t(8;15)?

Burkitt Lymphoma

6

What neoplasm is associated with t(11;14)?

Mantle Cell Lymphoma (B cell malignancy)

7

What neoplasm is associated with a deletion of 13q?

Chronic Lymphocytic Leukemia (CLL)

8

What diuretic causes hypoK, hypoMg, hypoCa, and ototoxicity?

Loop diuretics

9

What diuretic causes hypoK, hypoNa, hypERcalcemia, and hyperuricemia?

Thiazides

10

What brain tumor is benign, slow growing, arising from the arachnoid villi?

Meningioma

11

What brain tumor characteristically show Psammoma bodies?

Meningioma

12

mu receptor MOA?

GPCR activation of potassium efflux

13

What do you give Protamine for?

Heparin overdose

14

What chemical is in rodenticides (rat poison)?

Brodifacoum (4-hydroxycoumarin derivative)

15

What to give for brodifacoum toxicity?

Fresh frozen plasma and vit K

16

Where is a PDA heard best?

Left infraclavicular region

17

In what pathway is acetyl-CoA carboxylase the rate-limiting step?

Fatty acid synthesis

18

What does glycogen phosphorylase do?

Mediates glycogenolysis by removing single glucose residues from a-1,3-linkages

19

Deficient production of ketone bodies in starvation is likely due to what enzyme deficiency?

Acyl-CoA dehydrogenase

20

What is the most common cause of fetal hydronephrosis?

Inadequate canalization of the ureteropelvic junction in the metanephros

21

How does cirrhosis lead to spider angiomas?

Hyperestrinism

22

Transamination of Alanine's amino group to a-Ketoglutarate produces what two products?

Pyruvate and Glutamate

23

Polyene antifungals MOA?

Bind ergosterol molecules in fungal cell membranes, creating pores leading to lysis

24

Triazoles MOA?

Inhibit ergosterol SYNTHESIS

25

Echinocandins ("-fungin") MOA?

Inhibit glucan synthesis (fungal cell wall component)

26

Flucytosine antifungal MOA?

Converted to 5-fluorouracil and interferes with RNA and protein synthesis

27

Triad of congenital rubella?

Cataracts, sensorineural deafness, PDA

28

What type of vax to prevent congenital rubella?

Live attenuated virus vax in NON-pregnant women

29

What is the drug maintenance dose equation?

MD = Cpss x CL/bioavailability

30

What is the loading dose equation?

LD = Vd x Cpss/bioavailability

31

What is the drug half life equation?

t1/2 = Vd x 0.7/CL

32

What function does N-acetylcysteine serve in CF?

Mucolytic agent that cleaves disulfide bonds in mucosal glycoproteins, loosening sputum

33

Which vinca alkaloid causes the most neurotoxocity?

Vincristine

34

In what cell cycle phase do vinca alkaloids halt tumor cells?

M phase

35

What enzyme is lacking in Alkaptonuria?

Homogentisate oxidase

36

Conversion of tyrosine to what product is deficient in Alkaptonuria?

Fumarate

37

Exposure to what substance will result in eggshell calcification of hilar nodes and birefringent silica particles surrounded by fibrous tissue?

Silica