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Flashcards in 4/6 - UW 50 Deck (28):
1

Langerhans cells are different from Langhans cells! What are they?

LangERhans: dendritic cells in the skin and mucous membranes, with racquet shaped Birbeck granules

Langhans: multinucleated giant cell with horseshoe shaped arrangement of multiple nuclei

2

What cells have racquet shaped intracellular inclusions?

LangERhans cells in the skin and mucous membranes

3

What are Kupffer cells?

Hepatic macrophages

4

What are hepatic macrophages called?

Kupffer cells

5

What are Merkel cells?

Epidermal neuroendocrine cells that mediate TOUCH

6

What are the neuroendocrine cells in the epidermis that mediate touch?

Merkel cells

7

What are dendritic cells in the skin and mucous membranes called? What is specific to these cells on histology?

LangERhans (not Langhans) cells with intracellular "racquet shaped" Birbeck granules

8

How does Central retinal artery occlusion present clinically?

PainLESS, acute, monocular vision loss, with pale retina and a cherry red macula on fundoscopy

9

How does diabetic retinopathy present clinically?

Blurry vision, poor night vision, floaters, decreased night vision

10

What is amaurosis fugax?

Painless, TRANSIENT (a few seconds), monocular vision loss caused by small embolus to opthalmic artery

11

What AA change is in HbS?

Nonpolar Valine replaces negatively charged Glutamate in beta globin

12

What is the AA change in HbC?

Positively charged Lysine replaces negative Glutamate in beta chain

13

Which hemoglobinopathy has a Val in place of a Glu?

HbS

14

Which hemoglobinopathy has a Lys in place of a Glu?

HbC

15

What nerves enter the orbit through the Superior Orbital Fissure?

CN III
CN IV
CN V1
CN VI

16

Where does blunt aortic injury usually tear the aorta?

At the aortic isthmus where it is attached to the ligamentum arteriosum

17

Aside from Aspergillus, what else can produce ring enhancing lesions?

Toxoplasma (obligate intracellular protozoan)

18

Hypertensive crisis after food (cheese, sausage, wine) = ???

MAOI usage!
Isocarboxazid
Selegiline
Tranylcypromine
Phenelzine
"MAO IS SELling TRAc PHones"

19

How do colitis-associated carcinoma differ from sporadic colorectal carcinoma?

1. younger onset
2. from flat, nonpolypoid dysplasia
3. mucinous, signet ring
4. early p53, late APC
5. proximal colon, multifocal

20

What is the pathophys of Pick's disease?

Dementia (social disinhibition, abnormal speech, flat emotions) due to ATROPHY of frontotemporal regions

21

When do you see anti-histone ab?

Drug induced lupus

22

What hypercoagulable state can causes recurrent miscarriages?

Antiphospholipid syndrome

23

What disease should be considered in an elderly patient presenting with:
1. fatigue (anemia)
2. constipation (hyperCa)
3. back/rib pain (osteoclasts)
4. renal failure

Multiple Myeloma

24

What do medullary thyroid tumors secrete?

Calcitonin

25

What is the mutation that causes familial medullary thyroid cancer?

RET (tyrosine kinase receptor)

26

Amyloidosis of what organ contains amylin?

Pancreas

27

What causes an increased ESR during inflammation?

TNF-a, IL-1, and IL-6 mediate systemic inflammation, including ESR.

28

What is the most common benign liver tumor?

Cavernous hemangioma