4/4 - UW 45

Question 1

In what phase are primary oocytes arrested by the 5th month of gestation?

Answer 1

Prophase I

Question 2

In what phase are secondary oocytes arrested at ovulation?

Answer 2

Metaphase II

Question 3

What is the “triad” of Wiskott-Aldrich syndrome?

Answer 3

Eczema
Recurrent infections
Thrombocytopenia

Question 4

What is the “triad” of Hemolytic Uremic Syndrome?

Answer 4

Hemolytic = microangiopathic hemolytic anemia

Uremic = ARF

Also, thrombocytopenia

Question 5

What is a drug that commonly causes aplastic anemia?

Answer 5

Chloramphenicol

Question 6

What is an infection that commonly causes aplastic anemia in patients with sickle cell disease?

Answer 6

Parvovirus B19

Question 7

What is the “triad” of Chediak-Higashi syndrome?

Answer 7

Oculocutaneous albinism
Peripheral neuropathy
Immunodeficiency of phagocytes (dysfunction of phagosome-lysosome fusion)

Question 8

What are the 2 types of WBCs that compose host defense against Candida?

Answer 8

T cells: superficial infx

Neutrophils: disseminated infx

Question 9

What is the most commonly affected site for endometriosis?

Answer 9

Ovaries

Question 10

What can cause “chocolate cysts” in the ovaries?

Answer 10

Old blood from ectopic endometrium (endometriosis)

Question 11

What are two anatomical findings in endometriosis?

Answer 11

Nodularity of the uterosacral ligament

Fixed retroversion

Question 12

What are the AAs with 3 titratable protons?

Answer 12

Histidine
Arginine
Lysine
Aspartic acid
Glutamic acid
Cysteine
Tyrosine

Question 13

What percent of filtered water is reabsorbed by the proximal tubules?

Answer 13

> 60%! (isosmotically)

Question 14

What is one cause of pancreatic beta cell failure in T2DM?

Answer 14

Amyloid deposition

Question 15

What are the sequelae to large dose of vitamin E?

Answer 15

Adults: Hemorrhagic stroke

Infants: Necrotizing enterocolitis

Question 16

What are the sequelae to large dose of vitamin A?

Answer 16

Intracranial HTN (papilledema), skin changes (dry skin), and HSM

Question 17

In addition to water, what else does ADH increase permeability to in the medullary collecting ducts?

Answer 17

Urea

Question 18

What biochemical process is vit C necessary for?

Answer 18

HYDROXYLATION of proline and lysine residues in pro-collagen

Question 19

What biochemical process is Thiamine necessary for?

Answer 19

Coenzyme for DECARBOXYLATION of (pyruvate to acetyl CoA) and (alpha ketoglutarate to succinyl CoA)

Question 20

What is folate important for the synthesis of?

Answer 20

Purine and Thymidine

Question 21

What TB drug works best at acidic pH?

Answer 21

Pyrazinamide

Question 22

What cranial pathology is suggested in patients with ADPKD?

Answer 22

Berry aneurysms

Question 23

What drug is best for cerebral vasospasms following SAH?

Answer 23

Nimodipine

Question 24

What suffix denotes a bisphosphonate (osteoporosis drug analogous to pyrophosphate)?

Answer 24

“-dronate”

Question 25

What is the most common CNS neoplasm in immunosuppressed patients?

Answer 25

Primary CNS pymphoma

Question 26

What is the most common lung cancer in non-smokers and women?

Answer 26

Adenocarcinoma (40-50%, peripheral lung)

Question 27

Which lung cancer causes hypercalcemia?

Answer 27

SQUAMOUS cell carcinoma

Question 28

Which lung caner causes Cushing syndrome, SIADH, or Lambert-Eaton syndrome?

Answer 28

SMALL cell carcinoma

Question 29

Which lung cancers are most associated with smoking?

Answer 29

Small cell carcinoma Squamous cell carcinoma (Both typically occur in the central lung, in major bronchi)

Question 30

Which lung cancer is associated with gynecomastia and galactorrhea?

Answer 30

Large cell carcinoma

Question 31

What is the most important risk factor for mesothelioma?

Answer 31

Asbestos

Question 32

What drug mechanism is indicated by the suffix "-nib"

Answer 32

Kinase inhibitor (eg Imatinib is a tyrosine kinase inhibitor)

Question 33

What skin disorder is characterized by hyperparakeratosis, acanthosis, elongation of the rete ridges, mitotic activity above the epidermal basal layer, and a reduced/absent stratum granulosum?

Answer 33

Psoriasis