Flashcards in 3/22 - UW 17 Deck (58)
What is digital clubbing caused by?
Hypoxic conditions: Heart or lung disease, IBD, hyperthyroidism, malabsorption
What kind of nuclear material is in the mitochondria?
mtDNA is a small, circular chromosome coding for 14 proteins and their associated rRNA and tRNA
What MRSA tx causes Red Man Syndrome and nephrotoxicity? MOA?
Vanc, blocks glycopeptide polymerization be binding to D-alanyl-D-alanine
What is Red Man Syndrome?
Due to vancomycin: flushing or rash on face, neck, torso due to nonspecific mast cell degranulation, NOT IgE-mediated
What MRSA tx causes myopathy and CPK elevation, that is inactivated by surfactant? MOA?
Daptomycin, depolarizes cellular membrane
What MRSA tx causes thrombocytopenia and optic neuritis, and increases risk for serotonin syndrome? MOA?
Linezolid, inhibits 50S subunit
What street drug causes nystagmus?
What street drug causes chest pain and sz?
What street drug causes choreiform movements?
Blocks reuptake of DA, NE, 5HT in CNS
Phencyclidine (PCP) MOA?
Antagonizes NMDA rececptor
Guanosine analog: first phosphorylated by viral thymidine kinase (rate limiting step) to monophosphate, then to active triphosphate form
Why are EBV and CMV less susceptible to acyclovir than HSV and VZV?
Different thymidine kinase limits ability to activate acyclovir by phosphorylation
Why is CMV more sensitive to ganciclovir than other herpesviruses?
Differences in viral DNA polymerase structure
What is the primary site of rRNA synthesis?
What do RNA polymerase I, II, and III do?
RPII: mRNA, snRNA, miRNA
RPIII: tRNA, 5S rRNA
What is the fxn of Secretin?
Pancreatic BICARB secretion
What is the effect of CCK on the gallbladder? What is it secreted by?
Contraction, secreted by duodenal and jejunal I cells
What is the fxn of Gastrin?
Secretion of gastric acid, and gastric motility
What is an antidepressant that doesn't have sexual dysfunction side effects?
What CN carries motor innervation to the tongue?
Hypoglossal (CN XII), except the palatoglossus muscle (CN X)
What CNs carry general sensory from the tongue?
Anterior 2/3: mandibular branch of trigeminal (CN V3)
Posterior 1/3: glossopharyngial (CN IX)
Posterior part of tongue root: CN X
What CNs carry gustatory sensation from the tongue?
Anterior 2/3: chorda tympani of facial nerve (CN VII)
Posterior 1/3: glossopharyngeal (CN IX)
Posterior of tongue root: CN X
Jejunal ulcers is strongly suggestive of what neoplasm?
Gastrinomas: neuroendocrine tumors of the pancreas, peripancreatic tissue, or duodenum
Sx of VIPoma?
Intractable diarrhea, metabolic acidosis, hypokalemia
With gout, what accumulates in the synovial fluid and forms crystals?
Monosodium urate (uric acid salt)
With gout, levels of what increases in the serum?
What is lead time bias?
Bias in lead time (time between detection and outcome) due to different detection methods, without actual change in time to outcome
What is suggested with fatigue, bradycardia, weight fain, and slowed DTRs?