Flashcards in 3/22 - UW 17 Deck (58)
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1
What is digital clubbing caused by?
Hypoxic conditions: Heart or lung disease, IBD, hyperthyroidism, malabsorption
2
What kind of nuclear material is in the mitochondria?
mtDNA is a small, circular chromosome coding for 14 proteins and their associated rRNA and tRNA
3
What MRSA tx causes Red Man Syndrome and nephrotoxicity? MOA?
Vanc, blocks glycopeptide polymerization be binding to D-alanyl-D-alanine
4
What is Red Man Syndrome?
Due to vancomycin: flushing or rash on face, neck, torso due to nonspecific mast cell degranulation, NOT IgE-mediated
5
What MRSA tx causes myopathy and CPK elevation, that is inactivated by surfactant? MOA?
Daptomycin, depolarizes cellular membrane
6
What MRSA tx causes thrombocytopenia and optic neuritis, and increases risk for serotonin syndrome? MOA?
Linezolid, inhibits 50S subunit
7
What street drug causes nystagmus?
Phencyclindine (PCP)
8
What street drug causes chest pain and sz?
Cocaine
9
What street drug causes choreiform movements?
Meth
10
Cocaine MOA?
Blocks reuptake of DA, NE, 5HT in CNS
11
Phencyclidine (PCP) MOA?
Antagonizes NMDA rececptor
12
Acyclovir MOA?
Guanosine analog: first phosphorylated by viral thymidine kinase (rate limiting step) to monophosphate, then to active triphosphate form
13
Why are EBV and CMV less susceptible to acyclovir than HSV and VZV?
Different thymidine kinase limits ability to activate acyclovir by phosphorylation
14
Why is CMV more sensitive to ganciclovir than other herpesviruses?
Differences in viral DNA polymerase structure
15
What is the primary site of rRNA synthesis?
Nucleolus
16
What do RNA polymerase I, II, and III do?
RPI: rRNA
RPII: mRNA, snRNA, miRNA
RPIII: tRNA, 5S rRNA
17
What is the fxn of Secretin?
Pancreatic BICARB secretion
18
What is the effect of CCK on the gallbladder? What is it secreted by?
Contraction, secreted by duodenal and jejunal I cells
19
What is the fxn of Gastrin?
Secretion of gastric acid, and gastric motility
20
What is an antidepressant that doesn't have sexual dysfunction side effects?
Bupropion
21
What CN carries motor innervation to the tongue?
Hypoglossal (CN XII), except the palatoglossus muscle (CN X)
22
What CNs carry general sensory from the tongue?
Anterior 2/3: mandibular branch of trigeminal (CN V3)
Posterior 1/3: glossopharyngial (CN IX)
Posterior part of tongue root: CN X
23
What CNs carry gustatory sensation from the tongue?
Anterior 2/3: chorda tympani of facial nerve (CN VII)
Posterior 1/3: glossopharyngeal (CN IX)
Posterior of tongue root: CN X
24
Jejunal ulcers is strongly suggestive of what neoplasm?
Gastrinomas: neuroendocrine tumors of the pancreas, peripancreatic tissue, or duodenum
25
Sx of VIPoma?
Intractable diarrhea, metabolic acidosis, hypokalemia
26
With gout, what accumulates in the synovial fluid and forms crystals?
Monosodium urate (uric acid salt)
27
With gout, levels of what increases in the serum?
Uric acid
28
What is lead time bias?
Bias in lead time (time between detection and outcome) due to different detection methods, without actual change in time to outcome
29
What is suggested with fatigue, bradycardia, weight fain, and slowed DTRs?
Hypothyroidism
30
