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Flashcards in 2/28 Deck (32):
1

Crescent shaped Bowman's capsule?

Rapidly progressive glomerulonephritis

2

RPGN crescents consist of what cells? What substance?

Glomerular parietal cells Monocytes Macrophages Fibrin

3

What type of valvular insufficiency is characterized by a holosystolic murmur?

Mitral regurgitation (MR)

4

What pathology is associated with an S3 heart sound?

Increased LV filling during diastole... Associated with MR, CHF

5

What pathology is associated with an S4 heart sound?

"Atrial kick", high atrial pressure, stiff LV wall... Associated with LVH

6

Atopic dermatitis usually spares which area of the skin?

Diaper area

7

In older children, atopic dermatitis manifests as lichenification in what dermatologic distribution?

Flexural: neck wrists antecubital fossa popliteal fossa

8

What three symptoms are included in the "allergic triad"?

Atopic dermatitis (eczema) Allergic rhinitis Asthma

9

What dermatologic pathology is associated with Gluten enteropathy?

Dermatitis herpetiformis

10

What decades of life are associated with dermatitis herpetiformis?

4th and 5th, uncommon in children

11

What neural sx and organism are associated with Guillain-Barre?

Neural: ascending paralysis post febrile illness Organism: Campylobacter jejuni

12

Toxin penetration through blood nerve barrier leading to peripheral neuropathy is associated with which organism?

Diptheria

13

What brain structure is affected in Huntington's disease?

Caudate nucleus

14

Type of epithelium in the following organs: Ovaries Fallopian tubes Uterus Cervix Vagina

Ovaries: simple cuboidal Fallopian tubes: simple columnar Uterus: simple (pseudostratified) columnar Cervix: simple columnar and stratified squamous Vagina: stratified squamous

15

What are the antiarrhythmic agents that can cause torsades de pointes?

Class IA: Quinidine Procainamide Disopyramide Class III: Ibutilide Dofetilide Sotalol

16

PAS positive globules in hepatocytes indicates deficiency of what?

Alpha 1 antitrypsin

17

Alpha 1 antitrypsin deficiency will lead to what lung pathology?

Interalveolar septa destruction

Panacinar emphysema

18

Brown (not black) pigment stones are typically secondary to infection by which organisms?

E. coli Ascaris lumbricoides Opisthorchis sinensis

19

Organisms in which genus lacks peptidoglycan cell walls?

Mycoplasma Cannot use cell wall synthesis inhibitors (penicillins, cephalosporins, carbapenems, vancomycin) Can use antiribosomal agents (macrolides, tetracyclines, fluoroquinolones)

20

What to give to improve bladder emptying? Mechanism?

Bethanechol Muscarinic agonist stimulates detrussor muscle

21

Mechanism of finasteride? Uses?

5alpha reductase inhibitor Treats BPH, male baldness

22

What is honey often contaminated with?

C. botulinum

23

What topical antifungal should be used for thrush in immunocompetent patients?

Nystatin

24

Purulent urethritis from N. gonorrhoeae and/or C. trachomatis must be treated with what?

BOTH: 3rd gen ceph (ceftriaxone) for gonorrhea Tetracycline/Macrolide (doxy or azithro) for chlamydia

25

Insecticide is associated with what poisoning?

Arsenic

26

Arsenic poisoning is associated with what odor on breath?

Garlic

27

Drug of choice for arsenic poisoning?

Dimercaprol (It has narrow therapeutic index, causes nephrotoxicity and HTN)

28

Oseltamivir MoA?

Neuraminidase inhibitor, prevents virus release (aka Tamiflu, for influenze A and B)

29

What are the arginine derivatives?

Urea NO Creatine

30

"Owl's eyes" refer to what cells? What pathology are they associated with?

Reed Sternberg cells (giant binucleated cell) associated with Hodgkin's lymphoma

31

Demyelinated plaques are associated with what disease?

MS

32

What lab test for monitoring diabetic nephropathy?

Albuminuria