Adrenergic Pharmacology Flashcards Preview

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Flashcards in Adrenergic Pharmacology Deck (16):
1

Primary transmitter at the sympathetic postganglionic neuron-effector cell synapses in most tissue

Norepinephrine

Exceptions:
Eccrine sweat glands
Vasodilator sympathetic forbears in skeletal muscles

MNEMONICS
Dopamine vasoDilates renal blood vessels while norepinephrine vasoconstriction them.

2

Which drug inhibits tyrosine hydroxylase, which hdroxylates tryosine to dopa?

Metyrosine

3

What class of drugs increase the stores of norepinephrine and dopamine?

Monoamine oxidase inhibitors

4

What drug irreversibly blocks the vesicular monoamine transporter (VMAT)?
Side effects include suicidal ideation.

Reserpine

5

What drug inhibits the release of norepinephrine?
What promote its release? (2)

Guanethidine (side effects include severe psychiatric depression and suicidal ideation)
Amphetamine, tyramine

6

What drugs inhibit the diffusion and reuptake vie norepinephrine transporters and dopamine transporters in the synaptic cleft?

Cocaine
Tricyclic antidepressants

7

What drugs inhibit metabolism by MAO(monoamine oxidase) and COMT(catechol-O-methyltransferase)?

MAO inhibitors (TIP: tranylcypromine, isocarboxazid, phenelzine)
COMT inhibitors (tolcapone, entacapone)

8

What adrenoreceptor is being referred to?
Located in effector tissues, smooth muscle, and glands.
Gq mechanism

Alpha 1

9

What adrenoreceptor is being referred to?
IP3 and DAG as second messengers
Increases calcium; causes contraction and secretion
Contracts pupillary dilator muscle (mydriasis)
Contacts pilomotor smooth muscle (erects hair)
Stimulates glycogenolysis

Alpha 1

10

What adrenoreceptor is being referred to?
Located in nerve endings and smooth muscle.
Gi mechanism

Alpha 2

11

What adrenoreceptor is being referred to?
Causes a decrease in cAMP
Decreases transmitter release; causes contraction on some vascular smooth muscle

Alpha 2

12

What adrenoreceptor is being referred to?
Located in cardiac muscle and juxtaglomerular apparatus.
Gs mechanism
Increases cAMP
Increases heart rate and force
Increases renin release

Beta 1

13

What adrenoreceptor is being referred to?
Located in liver, heart, smooth muscle
Gs mechanism
Increases cAMP
Increases glycogenolysis; increases heart rate and force; relaxes smooth muscles in the airway, uterus, and vascular smooth muscle.

Beta 2

14

What adrenoreceptor is being referred to?
Located in adipose cells
Gs mechanism
Increases cAMP
Increases lipolysis

Beta 3

15

What adrenoreceptor is being referred to?
Located in renal and other splanchnic blood vessels
Gs mechanism
Renal vascular smooth muscle

Dopamine 1 (D1)

16

What adrenoreceptor is being referred to?
Located in nerve terminals
Inhibits adenylyl cyclase
Important in the treatment of schizophrenia

Dopamine 2 (D2)

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