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Flashcards in Diuretics Deck (13):
1

A diuretic used for glaucoma, mountain sickness, and edema with alkalosis. Side effects include hyperchloremic metabolic acidosis and hepatic encephalopathy in cirrhotic patients.

Acetazlamide

MNEMONIC: ACIDazolamide causes ACIDOsis

2

True or False.
Efficacy of furosemide and hydrochlorothiazide is decreased by NSAIDs.

True

3

Loop diuretic toxicities: (6)

OH DANG!
Ototoxicity
Hypokalemia
Dehydration
Allergy to sulfa
Nephritis
Gout

4

In the distal convoluted tubule, the calcium is also reabsorbed in this segment under the control of _____________ hormone.

parathyroid

5

Thiazide diuretics toxicity: (4)

HyperGLUC
hyperglycemia
Hyperuricemia
hyperlipidemia
hyperuricemia
hypercalcemia

6

Steroid inhibitor of cytoplasmic aldosterone receptors in cortical collecting ducts. Reduces potassium excretion.
Side effects include gynecomastia.

Spironolactone (aldosterone antagonist)

SimD: Eplerenone

7

Inhibitor of ENaC in cortical collecting duct. Side effects include acute renal failure (with indomethacin).

Amiloride

SimD: Triamterene

8

Examples of potassium-sparing diuretics (4)

The K STAEs (stays) with K-sparing diuretics:
Spironolactone
Triamterene
Amiloride
Eplerenone

9

Which drugs (not necessarily diuretics) can cause gynecomastia?

DACKS (related to chicks):
Digoxin
Alcohol
Cimetidine
Ketoconazole
Spironolactone

10

Examples of osmotic diuretics (4)

Mannitol
Isosorbide
Glycerin
Urea

11

Site of action of a ADH agonists and antagonists

Medullary collecting duct

12

Agonist at V1(blood vessel) and V2(collecting ducts) receptors. Activate insertion of aquaporin water channels in the collecting tubule.
Uses include central diabetes insipidus, nocturnal enuresis, hemophilia, and von Willebrand's disease.

Antidiuretic hormone a.k.a. vasopressin
SimD: desmopressin

13

Antagonist at V1 and V2 receptors. Used in SIADH and hyponatremia.

NOTE: ___________________ may occur with rapid correction of hyponatremia.

Conivaptan
Tolvaptan
Lixivaptan
Demeclocycline (SE: renal failure, bone and teeth abnormalities)
Lithium (SE: renal failure)

Central pontine myelinosis

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