Antiseizure Drugs Flashcards Preview

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Flashcards in Antiseizure Drugs Deck (9):
1

A.k.a. Grand mal seizures

GTC

2

Anti-seizure drug which block voltage-gated Na channels only

Phenytoin

3

Anti-seizure drug which block voltage-gated Na channels and decreases glutamate release
Also for trigeminal neuralgia

Carbamazepine
SimD: oxcarbazepine, eslicarbazepine

4

Blocks high-frequency firing of neurons, modifies amino acid metabolism
Blocks Na-, Ca channels
Binds to GABA A receptors
Drug of choice for GTC and bipolar disorder(acute mania)
SE: teratogen - spina bifida
Inhibitor of CYP450 enzymes

Valproic acid

5

Decreases Ca2+ currents (T-type) in thalamus
DOC for absence seizures

Ethosuximide

6

Block Na and Ca channels, decreases glutamate
SE: SJS

Lamotrigine

7

Selectively binds synaptic vesicular protein SV2A
Modified synaptic release of glutamate and GABA
SE: hallucinations, psychosis
Not metabolized by CYP450

Levetiracetam

8

Multiple actions on synaptic function, propnanly via actions on phosphorylation (Na, Ca, GABA, AMPA-glutamate, carbonic anhydrase) -- antiseizure drug with most number of MOAs

Topiramate

9

Antiseizure drugs also for migraine (3)

Topiramate
Gabapentin
Phenytoin

(The Generics Pharmacy ang takbukan for migraine)

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