Drugs Used in Parkinsonism Flashcards Preview

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Flashcards in Drugs Used in Parkinsonism Deck (11):
1

Dopamine precursor
Primary drug for Parkinson's disease
Contraindicated in patients with history of psychosis
Hypertensive crisis occurs when used with MAO-I

Levodopa-Carbidopa

2

Partial agonist at dopamine D2 receptors in th Ped brain
Use: PD, levodopa intolerance, hyperprolactinemia

Bromocriptine

3

Partial agonist at D3 receptors in the brain
For PD, restless leg syndrome
Contraindicated in patients with active peptic ulcer disease, psychotic illness, or recent MI

Pramipexole

4

Partial agonist at dopamine D3 receptors
Antagonist at 5HT and alpha adrenoceptors
For off-periods (akinesia) of PD
Premedicate with trimethobemzamide to prevent nausea

Apomorphine (not related to morphine)

5

MAO-B inhibitor
Combination with meperidine causes agitation, delirium, death (fatal reaction)
Serotonin syndrome occurs when used with SSRIs

Selegiline

6

COMT inhibitor
SE: orange urine

Entacapone
SimD: tolcapone (hepatotoxicity)

7

Antiviral
For PD, influenza

Amantadine

8

Anticholinergic
For PD, extrapyramidal symptoms caused by antipsychotics

Benztropine

9

Tetrabenazine and reserpine are drugs used for ______________

Huntington's Disease

10

Haloperidol and pimozide are drugs used for _____________

Tourette's syndrome

11

Drugs for Parkinson's (BALSA mnemonic)

Bromocriptine
Amantadine
Levodopa/Carbidopa
Selegeline
Anticholinergics (benztropine)

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