Sympathomimetics Flashcards Preview

P Pha T > Sympathomimetics > Flashcards

Flashcards in Sympathomimetics Deck (17):
1

Activates alpha and beta receptors.
Drug of choice for anaphylaxis.
Can be used for cardiac arrest, asthma, COPD, and for hemostasis.

Epinephrine

2

Activates alpha and beta receptors (alpha > beta).
Used as last resort for cardiogenic shock.
Can be used for neurogenic shock
Compensatory vagal reflexes tend to overcome the direct positive chronotropic effect.

Norepinephrine

3

Activates alpha, beta, and D1 receptors.
Used in cardiogenic shock and heart failure.
Has a dose-dependent action
-- Low dose (_____ mcg/kg/min) - vasodilation in the splanchnic and renal vascular beds via ______ receptors
-- Medium (______ mcg/kg/min) - increased renal blood flow, heart rate, cardiac contractility, and cardiac output via ______ receptors
-- High doses (greater than _______ mcg/kg/min) - vasoconstriction and increased blood pressure via _______ receptors

Dopamine
1-5
D1
5-15
beta
15
alpha

MNEMONIC: DiBA Dopa?

4

Nonselectively activates beta adrenergic receptors.
Once used in asthma but is withdrawn from the market due to cardiovascular disturbance and arrhythmias.

Isoproterenol

MNEMONIC:
Isoproterenol is not a beta-blocker. It is a non-selective beta agonist.
I SOrry! Akala ko beta-blocker ka!

5

Activates alpha-1 receptors used as a nasal decongestant and mydriatic. May cause rebound nasal congestion (rhinitis medica mentosa). Ocular administration causes mydriasis without cycloplegia.

Phenylephrine

SimD: pseudoephedrine, oxymetazoline, xylomethazoline, tetrahydrazoline, naphazoline, midodrine

MNEMONIC for alpha-1 agonists:
-ine
"mga pangsipon"

6

Activates alpha-2 receptors.
Used for hypertension, cancer pain, and opioid withdrawal.
Side effects include rebound hypertension, sedation, and dry mouth.
To avoid rebound hypertension, taper use prior to discontinuation.
To treat rebound hypertension, administer _______________.

Clonidine
Phentolamine

7

Activates alpha-2 receptors.
Used for gestational hypertension, pre-eclampsia.
Side effects include sedation and hemolytic anemia (Coombs test positive)

Methyldopa

SimD: guanfacine, guanabenz, dexmedetomidine, tizanidine

8

Activates beta-1 receptors.
Used for cardiogenic shock and acute heart failure.
May also be used in cardiac arrest testing.

Dobutamine

9

Activates beta-2 receptors in bronchial smooth muscles, thereby causing bronchodilation.
Drug of choice for acute asthma attacks.

Salbutamol a.k.a. albuterol

SimD:
Terbutaline and ritoridine (used in tocolysis for preterm labor)

10

Sympathomimetic of choice for acute heart failure and septic shock

Beta-1 and D1 agonists (to increase cardiac output)

11

Sympathomimetic of choice for spinal shock. Used to induce hemostasis and decongestion

Alpha-1 agonist (vasoconstriction and temporary maintenance of BP)

12

Sympathomimetic of choice for bronchospasm and premature labor

Beta-2 agonist (bronchodilation, uterine smooth muscle relaxation)

13

Sympathomimetic of choice for glaucoma and hypertension

Alpha-2 agonist (to decrease BP)

14

Non selective beta-blocker used for hyperthyroidism, angina prophylaxis, hypertension, arrhythmias, migraine, performance anxiety.
Side effects include bronchospasm, AV block. Heart failure, CNS sedation, and erectile dysfunction.
Masks the premonitory symptoms of hypoglycemia in diabetics (tachycardia, tremor, anxiety).

Propranolol

SimD:
Carvedilol and labetalol (has combined alpha and beta blockade, hence may be used in pheochromocytoma) Think: CLAB
Pindolol, timolol, nadolol, levobunolol, metipranolol

15

Beta-blockers with intrinsic sympathomimetic activity (2)
They have a partial agonist activity which is an advantage in treating patients with asthma because these drugs are less likely to cause bronchospasm.

Pindolol
Acebutolol

16

Beta-blockers with no local anesthetic activity making them useful in the treatment of glaucoma (2)

Timolol
Betaxolol

17

Selective beta-1 blockers (5)

NABEAM:
Nebivolol
Acebutolol
Betaxolol
Esmolol
Alprenolol
Metoprolol

Decks in P Pha T Class (62):