Endo (Corticosteroids and Antagonists) Flashcards Preview

P Pha T > Endo (Corticosteroids and Antagonists) > Flashcards

Flashcards in Endo (Corticosteroids and Antagonists) Deck (7):
1

Used for acute adrenal insufficiency, insect bites, contact dermatitis, status asthamticus, thyroid storm
Short-acting, low-potency glucocorticoid

Hydrocortisone (cortisol)

2

Glucocorticoid used for a wide variety of inflammatory, allergic, autoimmune and neoplastic diseases, prevention of organ transplantation, asthma

Prednisone

3

Glucocorticoid which hastens fetal lung maturation

Betamethasone
Dexamethasone

Normal lecithin:sphingomyelin ratio is 2:1

4

Increases Na reabsorption, K and H excretion
Mineralocorticoid used for chronic adrenal insufficiency (Addison's disease), CAH, adrenal replacement therapy post adrenalectomy

Fludrocortisone
SimD: Deoxycortisone
--
ADdison's - ADrenal insufficiency
Conn's - adrenal exCess

5

Glucocorticoid synthesis inhibitor
Inhibits desmolase, blocking conversion of cholesterol to pregnenolone
Used for Cushing syndrome, breast cancer

Aminoglutethimide

6

Glucocorticoid synthesis inhibitor, azole antifungal
Inhibits cholesterol side-chain cleavage, cytochrome P450 enzymes, and other enzymes necessary for synthesis of all steroids
SE: hepatotoxicity

Ketoconazole

7

Glucocorticoid synthesis inhibitor
Drug of choice for pregnant patients with Cushing's syndrome
For diagnostic testing

Metyrapone

Decks in P Pha T Class (62):